Role of vitamin C and E supplementation on IL-6 in response to training
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Vitamin C and E supplementation has been shown to attenuate the acute exercise-induced increase in plasma interleukin-6 (IL-6) concentration. Here, we studied the effect of antioxidant vitamins on the regulation of IL-6 expression in muscle and the circulation in response to acute exercise before and after high-intensity endurance exercise training. Twenty-one young healthy men were allocated into either a vitamin (VT; vitamin C and E, n = 11) or a placebo (PL, n = 10) group. A 1-h acute bicycling exercise trial at 65% of maximal power output was performed before and after 12 wk of progressive endurance exercise training. In response to training, the acute exercise-induced IL-6 response was attenuated in PL (P <0.02), but not in VT (P = 0.82). However, no clear difference between groups was observed (group × training: P = 0.13). Endurance exercise training also attenuated the acute exercise-induced increase in muscle-IL-6 mRNA in both groups. Oxidative stress, assessed by plasma protein carbonyls concentration, was overall higher in the VT compared with the PL group (group effect: P <0.005). This was accompanied by a general increase in skeletal muscle mRNA expression of antioxidative enzymes, including catalase, copper-zinc superoxide dismutase, and glutathione peroxidase 1 mRNA expression in the VT group. However, skeletal muscle protein content of catalase, copper-zinc superoxide dismutase, or glutathione peroxidase 1 was not affected by training or supplementation. In conclusion, our results indicate that, although vitamin C and E supplementation may attenuate exercise-induced increases in plasma IL-6 there is no clear additive effect when combined with endurance training.
Original language | English |
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Journal | Journal of Applied Physiology |
Volume | 112 |
Issue number | 6 |
Pages (from-to) | 990-1000 |
Number of pages | 11 |
ISSN | 8750-7587 |
DOIs | |
Publication status | Published - 2012 |
- Adult, Antioxidants, Ascorbic Acid, Body Mass Index, Catalase, Dietary Supplements, Double-Blind Method, Exercise, Glutathione Peroxidase, Humans, Hydrocortisone, Interleukin 1 Receptor Antagonist Protein, Interleukin-6, Male, Muscle Proteins, Muscle, Skeletal, Oxidative Stress, Physical Endurance, Superoxide Dismutase, Vitamin E
Research areas
ID: 44385583