Effect of High Inspiratory Oxygen Fraction on Endothelial Dysfunction in Healthy Volunteers: A Randomized Controlled Cross-over Pilot Study
Research output: Contribution to journal › Journal article › Research › peer-review
It has been suggested that high inspiratory oxygen concentrations during anesthesia may be associated with higher postoperative mortality due to endothelial dysfunction. A randomized controlled crossover study was conducted with 25 healthy male volunteers. They inhaled an oxygen concentration of 30% and 80%. The endothelial function was assessed using noninvasive digital pulse amplitude tonometry (EndoPAT) supported by endothelial biomarkers. The difference in endothelial function between the 2 treatments was 0.05 (95% confidence interval, −0.36 to 0.27; P = .77). Endothelial biomarkers were unaffected. Inhalation of a high oxygen fraction in healthy volunteers did not result in a significant reduction of endothelial function.
Original language | English |
---|---|
Journal | Anesthesia and Analgesia |
Volume | 125 |
Issue number | 5 |
Pages (from-to) | 1793–1796 |
ISSN | 0003-2999 |
DOIs | |
Publication status | Published - 2017 |
ID: 183578589