Effect of High Inspiratory Oxygen Fraction on Endothelial Dysfunction in Healthy Volunteers: A Randomized Controlled Cross-over Pilot Study

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Effect of High Inspiratory Oxygen Fraction on Endothelial Dysfunction in Healthy Volunteers : A Randomized Controlled Cross-over Pilot Study. / Larsen, Mikkel Hjordt Holm; Ekeløf, Sara; Kokotovic, Dunja; Schou-Pedersen, Anne Marie Voigt; Lykkesfeldt, Jens; Gögenur, Ismael .

In: Anesthesia and Analgesia, Vol. 125, No. 5, 2017, p. 1793–1796.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Larsen, MHH, Ekeløf, S, Kokotovic, D, Schou-Pedersen, AMV, Lykkesfeldt, J & Gögenur, I 2017, 'Effect of High Inspiratory Oxygen Fraction on Endothelial Dysfunction in Healthy Volunteers: A Randomized Controlled Cross-over Pilot Study', Anesthesia and Analgesia, vol. 125, no. 5, pp. 1793–1796. https://doi.org/10.1213/ANE.0000000000002357

APA

Larsen, M. H. H., Ekeløf, S., Kokotovic, D., Schou-Pedersen, A. M. V., Lykkesfeldt, J., & Gögenur, I. (2017). Effect of High Inspiratory Oxygen Fraction on Endothelial Dysfunction in Healthy Volunteers: A Randomized Controlled Cross-over Pilot Study. Anesthesia and Analgesia, 125(5), 1793–1796. https://doi.org/10.1213/ANE.0000000000002357

Vancouver

Larsen MHH, Ekeløf S, Kokotovic D, Schou-Pedersen AMV, Lykkesfeldt J, Gögenur I. Effect of High Inspiratory Oxygen Fraction on Endothelial Dysfunction in Healthy Volunteers: A Randomized Controlled Cross-over Pilot Study. Anesthesia and Analgesia. 2017;125(5):1793–1796. https://doi.org/10.1213/ANE.0000000000002357

Author

Larsen, Mikkel Hjordt Holm ; Ekeløf, Sara ; Kokotovic, Dunja ; Schou-Pedersen, Anne Marie Voigt ; Lykkesfeldt, Jens ; Gögenur, Ismael . / Effect of High Inspiratory Oxygen Fraction on Endothelial Dysfunction in Healthy Volunteers : A Randomized Controlled Cross-over Pilot Study. In: Anesthesia and Analgesia. 2017 ; Vol. 125, No. 5. pp. 1793–1796.

Bibtex

@article{7279eb95bceb415fb340d470372449ce,
title = "Effect of High Inspiratory Oxygen Fraction on Endothelial Dysfunction in Healthy Volunteers: A Randomized Controlled Cross-over Pilot Study",
abstract = "It has been suggested that high inspiratory oxygen concentrations during anesthesia may be associated with higher postoperative mortality due to endothelial dysfunction. A randomized controlled crossover study was conducted with 25 healthy male volunteers. They inhaled an oxygen concentration of 30% and 80%. The endothelial function was assessed using noninvasive digital pulse amplitude tonometry (EndoPAT) supported by endothelial biomarkers. The difference in endothelial function between the 2 treatments was 0.05 (95% confidence interval, −0.36 to 0.27; P = .77). Endothelial biomarkers were unaffected. Inhalation of a high oxygen fraction in healthy volunteers did not result in a significant reduction of endothelial function.",
author = "Larsen, {Mikkel Hjordt Holm} and Sara Ekel{\o}f and Dunja Kokotovic and Schou-Pedersen, {Anne Marie Voigt} and Jens Lykkesfeldt and Ismael G{\"o}genur",
year = "2017",
doi = "10.1213/ANE.0000000000002357",
language = "English",
volume = "125",
pages = "1793–1796",
journal = "Anesthesia and Analgesia",
issn = "0003-2999",
publisher = "Lippincott Williams & Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - Effect of High Inspiratory Oxygen Fraction on Endothelial Dysfunction in Healthy Volunteers

T2 - A Randomized Controlled Cross-over Pilot Study

AU - Larsen, Mikkel Hjordt Holm

AU - Ekeløf, Sara

AU - Kokotovic, Dunja

AU - Schou-Pedersen, Anne Marie Voigt

AU - Lykkesfeldt, Jens

AU - Gögenur, Ismael

PY - 2017

Y1 - 2017

N2 - It has been suggested that high inspiratory oxygen concentrations during anesthesia may be associated with higher postoperative mortality due to endothelial dysfunction. A randomized controlled crossover study was conducted with 25 healthy male volunteers. They inhaled an oxygen concentration of 30% and 80%. The endothelial function was assessed using noninvasive digital pulse amplitude tonometry (EndoPAT) supported by endothelial biomarkers. The difference in endothelial function between the 2 treatments was 0.05 (95% confidence interval, −0.36 to 0.27; P = .77). Endothelial biomarkers were unaffected. Inhalation of a high oxygen fraction in healthy volunteers did not result in a significant reduction of endothelial function.

AB - It has been suggested that high inspiratory oxygen concentrations during anesthesia may be associated with higher postoperative mortality due to endothelial dysfunction. A randomized controlled crossover study was conducted with 25 healthy male volunteers. They inhaled an oxygen concentration of 30% and 80%. The endothelial function was assessed using noninvasive digital pulse amplitude tonometry (EndoPAT) supported by endothelial biomarkers. The difference in endothelial function between the 2 treatments was 0.05 (95% confidence interval, −0.36 to 0.27; P = .77). Endothelial biomarkers were unaffected. Inhalation of a high oxygen fraction in healthy volunteers did not result in a significant reduction of endothelial function.

U2 - 10.1213/ANE.0000000000002357

DO - 10.1213/ANE.0000000000002357

M3 - Journal article

C2 - 28922226

VL - 125

SP - 1793

EP - 1796

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

SN - 0003-2999

IS - 5

ER -

ID: 183578589