The kidneys play a central role in the clearance of rhGH in rats

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The kidneys play a central role in the clearance of rhGH in rats. / Vestergaard, Bill; Thygesen, Peter; Kreilgaard, Mads; Fels, Johannes Josef; Lykkesfeldt, Jens; Agerso, Henrik.

In: European Journal of Pharmaceutical Sciences, Vol. 86, 30.04.2016, p. 29-33.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Vestergaard, B, Thygesen, P, Kreilgaard, M, Fels, JJ, Lykkesfeldt, J & Agerso, H 2016, 'The kidneys play a central role in the clearance of rhGH in rats', European Journal of Pharmaceutical Sciences, vol. 86, pp. 29-33. https://doi.org/10.1016/j.ejps.2016.02.019

APA

Vestergaard, B., Thygesen, P., Kreilgaard, M., Fels, J. J., Lykkesfeldt, J., & Agerso, H. (2016). The kidneys play a central role in the clearance of rhGH in rats. European Journal of Pharmaceutical Sciences, 86, 29-33. https://doi.org/10.1016/j.ejps.2016.02.019

Vancouver

Vestergaard B, Thygesen P, Kreilgaard M, Fels JJ, Lykkesfeldt J, Agerso H. The kidneys play a central role in the clearance of rhGH in rats. European Journal of Pharmaceutical Sciences. 2016 Apr 30;86:29-33. https://doi.org/10.1016/j.ejps.2016.02.019

Author

Vestergaard, Bill ; Thygesen, Peter ; Kreilgaard, Mads ; Fels, Johannes Josef ; Lykkesfeldt, Jens ; Agerso, Henrik. / The kidneys play a central role in the clearance of rhGH in rats. In: European Journal of Pharmaceutical Sciences. 2016 ; Vol. 86. pp. 29-33.

Bibtex

@article{eaabdb25ec7148b390c27aa002449748,
title = "The kidneys play a central role in the clearance of rhGH in rats",
abstract = "The kidneys are thought to play an important role in the clearance of recombinant human growth hormone (rhGH), but the relative importance is not clear. Obtaining knowledge of clearance pathway is an important prerequisite for the development of new long acting growth hormone analogues targeted at treatment of patients with growth hormone disorders. The purpose of this study was to investigate the relative importance of the kidneys in the clearance of rhGH. The study employed a newly validated nephrectomy rat model and a population based pharmacokinetic approach to assess renal clearance of rhGH in non-anesthetized rats, anesthetized rats and in nephrectomized anesthetized rats. Clearance in non-anesthetized rats was 290 ml/h/kg. This was reduced to 185 ml/h/kg by anesthesia and further reduced to 18 ml/h/kg by nephrectomy. As nephrectomy was able to reduce clearance with 90%, we conclude that renal clearance plays a pivotal role in the elimination of rhGH in rats.",
keywords = "rhGH, Clearance, Kidney, Pharmacokinetics, Nephrectomy, Non-linear mixed effect modeling",
author = "Bill Vestergaard and Peter Thygesen and Mads Kreilgaard and Fels, {Johannes Josef} and Jens Lykkesfeldt and Henrik Agerso",
year = "2016",
month = apr,
day = "30",
doi = "10.1016/j.ejps.2016.02.019",
language = "English",
volume = "86",
pages = "29--33",
journal = "Norvegica Pharmaceutica Acta",
issn = "0928-0987",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The kidneys play a central role in the clearance of rhGH in rats

AU - Vestergaard, Bill

AU - Thygesen, Peter

AU - Kreilgaard, Mads

AU - Fels, Johannes Josef

AU - Lykkesfeldt, Jens

AU - Agerso, Henrik

PY - 2016/4/30

Y1 - 2016/4/30

N2 - The kidneys are thought to play an important role in the clearance of recombinant human growth hormone (rhGH), but the relative importance is not clear. Obtaining knowledge of clearance pathway is an important prerequisite for the development of new long acting growth hormone analogues targeted at treatment of patients with growth hormone disorders. The purpose of this study was to investigate the relative importance of the kidneys in the clearance of rhGH. The study employed a newly validated nephrectomy rat model and a population based pharmacokinetic approach to assess renal clearance of rhGH in non-anesthetized rats, anesthetized rats and in nephrectomized anesthetized rats. Clearance in non-anesthetized rats was 290 ml/h/kg. This was reduced to 185 ml/h/kg by anesthesia and further reduced to 18 ml/h/kg by nephrectomy. As nephrectomy was able to reduce clearance with 90%, we conclude that renal clearance plays a pivotal role in the elimination of rhGH in rats.

AB - The kidneys are thought to play an important role in the clearance of recombinant human growth hormone (rhGH), but the relative importance is not clear. Obtaining knowledge of clearance pathway is an important prerequisite for the development of new long acting growth hormone analogues targeted at treatment of patients with growth hormone disorders. The purpose of this study was to investigate the relative importance of the kidneys in the clearance of rhGH. The study employed a newly validated nephrectomy rat model and a population based pharmacokinetic approach to assess renal clearance of rhGH in non-anesthetized rats, anesthetized rats and in nephrectomized anesthetized rats. Clearance in non-anesthetized rats was 290 ml/h/kg. This was reduced to 185 ml/h/kg by anesthesia and further reduced to 18 ml/h/kg by nephrectomy. As nephrectomy was able to reduce clearance with 90%, we conclude that renal clearance plays a pivotal role in the elimination of rhGH in rats.

KW - rhGH

KW - Clearance

KW - Kidney

KW - Pharmacokinetics

KW - Nephrectomy

KW - Non-linear mixed effect modeling

U2 - 10.1016/j.ejps.2016.02.019

DO - 10.1016/j.ejps.2016.02.019

M3 - Journal article

C2 - 26946443

VL - 86

SP - 29

EP - 33

JO - Norvegica Pharmaceutica Acta

JF - Norvegica Pharmaceutica Acta

SN - 0928-0987

ER -

ID: 166451888