Plasma lipid oxidation predicts atherosclerotic status better than cholesterol in diabetic apolipoprotein E deficient mice
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Plasma lipid oxidation predicts atherosclerotic status better than cholesterol in diabetic apolipoprotein E deficient mice. / Petersen, Karen Ekkelund; Lykkesfeldt, Jens; Raun, Kirsten; Rakipovski, Gunaj.
In: Experimental Biology and Medicine (Maywood), Vol. 242, No. 1, 01.2017, p. 88-91.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Plasma lipid oxidation predicts atherosclerotic status better than cholesterol in diabetic apolipoprotein E deficient mice
AU - Petersen, Karen Ekkelund
AU - Lykkesfeldt, Jens
AU - Raun, Kirsten
AU - Rakipovski, Gunaj
PY - 2017/1
Y1 - 2017/1
N2 - Increased levels of oxidative stress have been suggested to play a detrimental role in the development of diabetes-related vascular complications. Here, we investigated whether the concentration of malondialdehyde, a marker of lipid oxidation correlated to the degree of aortic plaque lesions in a proatherogenic diabetic mouse model. Three groups of apolipoprotein E knockout mice were studied for 20 weeks, a control, a streptozotocin-induced diabetic, and a diabetic enalapril-treated group. Enalapril was hypothesized to lower oxidative stress level and thus the plaque burden. Both diabetic groups were significantly different from the control group as they had higher blood glucose, HbA1c, total cholesterol, low-density lipoprotein, very low-density lipoprotein, together with a lower high-density lipoprotein concentration and body weight. Animals in the diabetic group had significantly higher plaque area and plasma malondialdehyde than controls. The two diabetic groups did not differ significantly in any measured characteristic. In summary, there was a positive correlation between plasma malondialdehyde concentration and aorta plaque area in apolipoprotein E knockout. Even though further investigation of the role of lipid oxidation in the development of atherosclerosis is warranted, these results suggest that biomarkers of lipid oxidation may be of value in the evaluation of cardiovascular risk.
AB - Increased levels of oxidative stress have been suggested to play a detrimental role in the development of diabetes-related vascular complications. Here, we investigated whether the concentration of malondialdehyde, a marker of lipid oxidation correlated to the degree of aortic plaque lesions in a proatherogenic diabetic mouse model. Three groups of apolipoprotein E knockout mice were studied for 20 weeks, a control, a streptozotocin-induced diabetic, and a diabetic enalapril-treated group. Enalapril was hypothesized to lower oxidative stress level and thus the plaque burden. Both diabetic groups were significantly different from the control group as they had higher blood glucose, HbA1c, total cholesterol, low-density lipoprotein, very low-density lipoprotein, together with a lower high-density lipoprotein concentration and body weight. Animals in the diabetic group had significantly higher plaque area and plasma malondialdehyde than controls. The two diabetic groups did not differ significantly in any measured characteristic. In summary, there was a positive correlation between plasma malondialdehyde concentration and aorta plaque area in apolipoprotein E knockout. Even though further investigation of the role of lipid oxidation in the development of atherosclerosis is warranted, these results suggest that biomarkers of lipid oxidation may be of value in the evaluation of cardiovascular risk.
KW - Diabetes
KW - oxidative stress
KW - lipid oxidation
KW - atherosclerosis
KW - APOE((-/-)) mice
KW - malondialdehyde
U2 - 10.1177/1535370216650520
DO - 10.1177/1535370216650520
M3 - Journal article
C2 - 28044466
VL - 242
SP - 88
EP - 91
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
SN - 1535-3702
IS - 1
ER -
ID: 176694740