Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction

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Standard

Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction. / Halladin, Natalie L.; Busch, Sarah Victoria Ekeløf; Jensen, Svend Eggert; Aarøe, Jens; Kjærgaard, Benedict; Heegaard, Peter M. H.; Lykkesfeldt, Jens; Rosenberg, Jacob; Gögenür, Ismayil.

In: In Vivo, Vol. 28, 2014, p. 483-488.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Halladin, NL, Busch, SVE, Jensen, SE, Aarøe, J, Kjærgaard, B, Heegaard, PMH, Lykkesfeldt, J, Rosenberg, J & Gögenür, I 2014, 'Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction', In Vivo, vol. 28, pp. 483-488. <http://iv.iiarjournals.org/content/28/4/483.short>

APA

Halladin, N. L., Busch, S. V. E., Jensen, S. E., Aarøe, J., Kjærgaard, B., Heegaard, P. M. H., Lykkesfeldt, J., Rosenberg, J., & Gögenür, I. (2014). Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction. In Vivo, 28, 483-488. http://iv.iiarjournals.org/content/28/4/483.short

Vancouver

Halladin NL, Busch SVE, Jensen SE, Aarøe J, Kjærgaard B, Heegaard PMH et al. Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction. In Vivo. 2014;28:483-488.

Author

Halladin, Natalie L. ; Busch, Sarah Victoria Ekeløf ; Jensen, Svend Eggert ; Aarøe, Jens ; Kjærgaard, Benedict ; Heegaard, Peter M. H. ; Lykkesfeldt, Jens ; Rosenberg, Jacob ; Gögenür, Ismayil. / Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction. In: In Vivo. 2014 ; Vol. 28. pp. 483-488.

Bibtex

@article{69ea9e98561f4cc0be08a7f59348ab86,
title = "Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction",
abstract = "AIM: To test whether melatonin reduces oxidative and inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction.MATERIALS AND METHODS: Twenty pigs were randomized to receive a total dosage of 200 mg (0.4 mg/ml) of melatonin, or placebo immediately prior to reperfusion of a coronary artery balloon occlusion in a randomized, observer-blinded, placebo-controlled trial. We assessed high-sensitivity troponin T (hs-TnT), malondialdehyde and interleukin-1b, -6 and -10 at baseline, 30 min and 1, 2, 3 and 4 h after the start of reperfusion.RESULTS: Seventeen pigs completed the trial. There was an increase in hs-TnT, but no significant difference between the melatonin-treated and placebo-treated groups. There were no significant differences in development of any of the circulating plasma markers between the two groups.CONCLUSION: Melatonin treatment did not result in reduction of inflammatory or oxidative stress markers after experimental myocardial infarction compared to placebo.",
author = "Halladin, {Natalie L.} and Busch, {Sarah Victoria Ekel{\o}f} and Jensen, {Svend Eggert} and Jens Aar{\o}e and Benedict Kj{\ae}rgaard and Heegaard, {Peter M. H.} and Jens Lykkesfeldt and Jacob Rosenberg and Ismayil G{\"o}gen{\"u}r",
note = "Copyright {\textcopyright} 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.",
year = "2014",
language = "English",
volume = "28",
pages = "483--488",
journal = "In Vivo",
issn = "0258-851X",
publisher = "International Institute of Anticancer Research",

}

RIS

TY - JOUR

T1 - Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction

AU - Halladin, Natalie L.

AU - Busch, Sarah Victoria Ekeløf

AU - Jensen, Svend Eggert

AU - Aarøe, Jens

AU - Kjærgaard, Benedict

AU - Heegaard, Peter M. H.

AU - Lykkesfeldt, Jens

AU - Rosenberg, Jacob

AU - Gögenür, Ismayil

N1 - Copyright © 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

PY - 2014

Y1 - 2014

N2 - AIM: To test whether melatonin reduces oxidative and inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction.MATERIALS AND METHODS: Twenty pigs were randomized to receive a total dosage of 200 mg (0.4 mg/ml) of melatonin, or placebo immediately prior to reperfusion of a coronary artery balloon occlusion in a randomized, observer-blinded, placebo-controlled trial. We assessed high-sensitivity troponin T (hs-TnT), malondialdehyde and interleukin-1b, -6 and -10 at baseline, 30 min and 1, 2, 3 and 4 h after the start of reperfusion.RESULTS: Seventeen pigs completed the trial. There was an increase in hs-TnT, but no significant difference between the melatonin-treated and placebo-treated groups. There were no significant differences in development of any of the circulating plasma markers between the two groups.CONCLUSION: Melatonin treatment did not result in reduction of inflammatory or oxidative stress markers after experimental myocardial infarction compared to placebo.

AB - AIM: To test whether melatonin reduces oxidative and inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction.MATERIALS AND METHODS: Twenty pigs were randomized to receive a total dosage of 200 mg (0.4 mg/ml) of melatonin, or placebo immediately prior to reperfusion of a coronary artery balloon occlusion in a randomized, observer-blinded, placebo-controlled trial. We assessed high-sensitivity troponin T (hs-TnT), malondialdehyde and interleukin-1b, -6 and -10 at baseline, 30 min and 1, 2, 3 and 4 h after the start of reperfusion.RESULTS: Seventeen pigs completed the trial. There was an increase in hs-TnT, but no significant difference between the melatonin-treated and placebo-treated groups. There were no significant differences in development of any of the circulating plasma markers between the two groups.CONCLUSION: Melatonin treatment did not result in reduction of inflammatory or oxidative stress markers after experimental myocardial infarction compared to placebo.

M3 - Journal article

C2 - 24982213

VL - 28

SP - 483

EP - 488

JO - In Vivo

JF - In Vivo

SN - 0258-851X

ER -

ID: 124427145