Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs. / Tveden-Nyborg, Pernille; Vogt, Lucile; Schjoldager, Janne Gram; Jeannet, Natalie; Andersen, Stine Hasselholt; Paidi, Maya Devi; Christen, Stephan; Lykkesfeldt, Jens.

In: P L o S One, Vol. 7, No. 10, 2012.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tveden-Nyborg, P, Vogt, L, Schjoldager, JG, Jeannet, N, Andersen, SH, Paidi, MD, Christen, S & Lykkesfeldt, J 2012, 'Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs', P L o S One, vol. 7, no. 10. https://doi.org/10.1371/journal.pone.0048488

APA

Tveden-Nyborg, P., Vogt, L., Schjoldager, J. G., Jeannet, N., Andersen, S. H., Paidi, M. D., Christen, S., & Lykkesfeldt, J. (2012). Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs. P L o S One, 7(10). https://doi.org/10.1371/journal.pone.0048488

Vancouver

Tveden-Nyborg P, Vogt L, Schjoldager JG, Jeannet N, Andersen SH, Paidi MD et al. Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs. P L o S One. 2012;7(10). https://doi.org/10.1371/journal.pone.0048488

Author

Tveden-Nyborg, Pernille ; Vogt, Lucile ; Schjoldager, Janne Gram ; Jeannet, Natalie ; Andersen, Stine Hasselholt ; Paidi, Maya Devi ; Christen, Stephan ; Lykkesfeldt, Jens. / Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs. In: P L o S One. 2012 ; Vol. 7, No. 10.

Bibtex

@article{8d464206690f405fa114533429f43cdf,
title = "Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs",
abstract = "While having the highest vitamin C (VitC) concentrations in the body, specific functions of VitC in the brain have only recently been acknowledged. We have shown that postnatal VitC deficiency in guinea pigs causes impairment of hippocampal memory function and leads to 30% less neurons. This study investigates how prenatal VitC deficiency affects postnatal hippocampal development and if any such effect can be reversed by postnatal VitC repletion. Eighty pregnant Dunkin Hartley guinea pig dams were randomized into weight stratified groups receiving High (900 mg) or Low (100 mg) VitC per kg diet. Newborn pups (n = 157) were randomized into a total of four postnatal feeding regimens: High/High (Control); High/Low (Depleted), Low/Low (Deficient); and Low/High (Repleted). Proliferation and migration of newborn cells in the dentate gyrus was assessed by BrdU labeling and hippocampal volumes were determined by stereology. Prenatal VitC deficiency resulted in a significant reduction in postnatal hippocampal volume (P",
author = "Pernille Tveden-Nyborg and Lucile Vogt and Schjoldager, {Janne Gram} and Natalie Jeannet and Andersen, {Stine Hasselholt} and Paidi, {Maya Devi} and Stephan Christen and Jens Lykkesfeldt",
note = "e48488",
year = "2012",
doi = "10.1371/journal.pone.0048488",
language = "English",
volume = "7",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",

}

RIS

TY - JOUR

T1 - Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs

AU - Tveden-Nyborg, Pernille

AU - Vogt, Lucile

AU - Schjoldager, Janne Gram

AU - Jeannet, Natalie

AU - Andersen, Stine Hasselholt

AU - Paidi, Maya Devi

AU - Christen, Stephan

AU - Lykkesfeldt, Jens

N1 - e48488

PY - 2012

Y1 - 2012

N2 - While having the highest vitamin C (VitC) concentrations in the body, specific functions of VitC in the brain have only recently been acknowledged. We have shown that postnatal VitC deficiency in guinea pigs causes impairment of hippocampal memory function and leads to 30% less neurons. This study investigates how prenatal VitC deficiency affects postnatal hippocampal development and if any such effect can be reversed by postnatal VitC repletion. Eighty pregnant Dunkin Hartley guinea pig dams were randomized into weight stratified groups receiving High (900 mg) or Low (100 mg) VitC per kg diet. Newborn pups (n = 157) were randomized into a total of four postnatal feeding regimens: High/High (Control); High/Low (Depleted), Low/Low (Deficient); and Low/High (Repleted). Proliferation and migration of newborn cells in the dentate gyrus was assessed by BrdU labeling and hippocampal volumes were determined by stereology. Prenatal VitC deficiency resulted in a significant reduction in postnatal hippocampal volume (P

AB - While having the highest vitamin C (VitC) concentrations in the body, specific functions of VitC in the brain have only recently been acknowledged. We have shown that postnatal VitC deficiency in guinea pigs causes impairment of hippocampal memory function and leads to 30% less neurons. This study investigates how prenatal VitC deficiency affects postnatal hippocampal development and if any such effect can be reversed by postnatal VitC repletion. Eighty pregnant Dunkin Hartley guinea pig dams were randomized into weight stratified groups receiving High (900 mg) or Low (100 mg) VitC per kg diet. Newborn pups (n = 157) were randomized into a total of four postnatal feeding regimens: High/High (Control); High/Low (Depleted), Low/Low (Deficient); and Low/High (Repleted). Proliferation and migration of newborn cells in the dentate gyrus was assessed by BrdU labeling and hippocampal volumes were determined by stereology. Prenatal VitC deficiency resulted in a significant reduction in postnatal hippocampal volume (P

U2 - 10.1371/journal.pone.0048488

DO - 10.1371/journal.pone.0048488

M3 - Journal article

C2 - 23119033

VL - 7

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 10

ER -

ID: 43498331