High-fat feeding induces mobilization of vitamin C in obese prone rats

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High-fat feeding induces mobilization of vitamin C in obese prone rats. / Tranberg, B.; Hellgren, L. I.; Lykkesfeldt, J.; Hansen, A. K.

In: Research in Veterinary Science, Vol. 119, 2018, p. 167-169.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tranberg, B, Hellgren, LI, Lykkesfeldt, J & Hansen, AK 2018, 'High-fat feeding induces mobilization of vitamin C in obese prone rats', Research in Veterinary Science, vol. 119, pp. 167-169. https://doi.org/10.1016/j.rvsc.2018.06.011

APA

Tranberg, B., Hellgren, L. I., Lykkesfeldt, J., & Hansen, A. K. (2018). High-fat feeding induces mobilization of vitamin C in obese prone rats. Research in Veterinary Science, 119, 167-169. https://doi.org/10.1016/j.rvsc.2018.06.011

Vancouver

Tranberg B, Hellgren LI, Lykkesfeldt J, Hansen AK. High-fat feeding induces mobilization of vitamin C in obese prone rats. Research in Veterinary Science. 2018;119:167-169. https://doi.org/10.1016/j.rvsc.2018.06.011

Author

Tranberg, B. ; Hellgren, L. I. ; Lykkesfeldt, J. ; Hansen, A. K. / High-fat feeding induces mobilization of vitamin C in obese prone rats. In: Research in Veterinary Science. 2018 ; Vol. 119. pp. 167-169.

Bibtex

@article{e1798ff5a57b4e9aa6fa1889a2efa9d5,
title = "High-fat feeding induces mobilization of vitamin C in obese prone rats",
abstract = "In obesity and dyslipidemia, hydrolysis of triacylglycerol (TAG) into non-esterified fatty acids (NEFAs) may contribute to insulin resistance, and production of oxygenated, bioactive polyunsaturated fatty acids may increase oxidative stress. Here we show that after six weeks of high-fat feeding of obese prone rats (Crl:OP(CD), vitamin C was increased both in liver (P < 0.01) and plasma (P < 0.001), while both TAG (P < 0.01) and NEFA (P < 0.001) were lower than in low-fat fed control rats. Hepatic vitamin C biosynthesis was similar between groups, indicating that a new steady state level was established with a higher vitamin C level adequate for supplying the systemic needs. Glucose and insulin sensitivity were unaffected at this stage. Eventually, the mobilization of vitamin C may be seen as a mechanism to protect the host against insulin resistance.",
keywords = "High-fat diet, Insulin resistance, Obesity, Rat, Vitamin C",
author = "B. Tranberg and Hellgren, {L. I.} and J. Lykkesfeldt and Hansen, {A. K.}",
year = "2018",
doi = "10.1016/j.rvsc.2018.06.011",
language = "English",
volume = "119",
pages = "167--169",
journal = "Research in Veterinary Science",
issn = "0034-5288",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - High-fat feeding induces mobilization of vitamin C in obese prone rats

AU - Tranberg, B.

AU - Hellgren, L. I.

AU - Lykkesfeldt, J.

AU - Hansen, A. K.

PY - 2018

Y1 - 2018

N2 - In obesity and dyslipidemia, hydrolysis of triacylglycerol (TAG) into non-esterified fatty acids (NEFAs) may contribute to insulin resistance, and production of oxygenated, bioactive polyunsaturated fatty acids may increase oxidative stress. Here we show that after six weeks of high-fat feeding of obese prone rats (Crl:OP(CD), vitamin C was increased both in liver (P < 0.01) and plasma (P < 0.001), while both TAG (P < 0.01) and NEFA (P < 0.001) were lower than in low-fat fed control rats. Hepatic vitamin C biosynthesis was similar between groups, indicating that a new steady state level was established with a higher vitamin C level adequate for supplying the systemic needs. Glucose and insulin sensitivity were unaffected at this stage. Eventually, the mobilization of vitamin C may be seen as a mechanism to protect the host against insulin resistance.

AB - In obesity and dyslipidemia, hydrolysis of triacylglycerol (TAG) into non-esterified fatty acids (NEFAs) may contribute to insulin resistance, and production of oxygenated, bioactive polyunsaturated fatty acids may increase oxidative stress. Here we show that after six weeks of high-fat feeding of obese prone rats (Crl:OP(CD), vitamin C was increased both in liver (P < 0.01) and plasma (P < 0.001), while both TAG (P < 0.01) and NEFA (P < 0.001) were lower than in low-fat fed control rats. Hepatic vitamin C biosynthesis was similar between groups, indicating that a new steady state level was established with a higher vitamin C level adequate for supplying the systemic needs. Glucose and insulin sensitivity were unaffected at this stage. Eventually, the mobilization of vitamin C may be seen as a mechanism to protect the host against insulin resistance.

KW - High-fat diet

KW - Insulin resistance

KW - Obesity

KW - Rat

KW - Vitamin C

U2 - 10.1016/j.rvsc.2018.06.011

DO - 10.1016/j.rvsc.2018.06.011

M3 - Journal article

C2 - 29945036

AN - SCOPUS:85048853890

VL - 119

SP - 167

EP - 169

JO - Research in Veterinary Science

JF - Research in Veterinary Science

SN - 0034-5288

ER -

ID: 201907246