Endothelial cell death and intimal foam cell accumulation in the coronary artery of infected hypercholesterolemic minipigs

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Endothelial cell death and intimal foam cell accumulation in the coronary artery of infected hypercholesterolemic minipigs. / Birck, Malene Muusfeldt; Saraste, Antti; Hyttel, Poul; Odermarsky, Michal; Liuba, Petru; Saukko, Pekka; Hansen, Axel Jacob Kornerup; Pesonen, Erkki.

In: Journal of Cardiovascular Translational Research, Vol. 6, No. 4, 2013, p. 579-587.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Birck, MM, Saraste, A, Hyttel, P, Odermarsky, M, Liuba, P, Saukko, P, Hansen, AJK & Pesonen, E 2013, 'Endothelial cell death and intimal foam cell accumulation in the coronary artery of infected hypercholesterolemic minipigs', Journal of Cardiovascular Translational Research, vol. 6, no. 4, pp. 579-587. https://doi.org/10.1007/s12265-013-9463-2

APA

Birck, M. M., Saraste, A., Hyttel, P., Odermarsky, M., Liuba, P., Saukko, P., Hansen, A. J. K., & Pesonen, E. (2013). Endothelial cell death and intimal foam cell accumulation in the coronary artery of infected hypercholesterolemic minipigs. Journal of Cardiovascular Translational Research, 6(4), 579-587. https://doi.org/10.1007/s12265-013-9463-2

Vancouver

Birck MM, Saraste A, Hyttel P, Odermarsky M, Liuba P, Saukko P et al. Endothelial cell death and intimal foam cell accumulation in the coronary artery of infected hypercholesterolemic minipigs. Journal of Cardiovascular Translational Research. 2013;6(4):579-587. https://doi.org/10.1007/s12265-013-9463-2

Author

Birck, Malene Muusfeldt ; Saraste, Antti ; Hyttel, Poul ; Odermarsky, Michal ; Liuba, Petru ; Saukko, Pekka ; Hansen, Axel Jacob Kornerup ; Pesonen, Erkki. / Endothelial cell death and intimal foam cell accumulation in the coronary artery of infected hypercholesterolemic minipigs. In: Journal of Cardiovascular Translational Research. 2013 ; Vol. 6, No. 4. pp. 579-587.

Bibtex

@article{9d693bc94c0b4e3eb1acec9d22b32675,
title = "Endothelial cell death and intimal foam cell accumulation in the coronary artery of infected hypercholesterolemic minipigs",
abstract = "Apoptosis of endothelial cells (ECs) has been suggested to play a role in atherosclerosis. We studied the synergism of hypercholesterolemia with Chlamydia pneumoniae and influenza virus infections on EC morphology and intimal changes in a minipig model. The coronary artery was excised at euthanasia (19 weeks of age) and serial sections were processed for the detection of EC apoptosis, histology, and transmission electron microscopy (TEM) studies. There was a significantly higher number of TUNEL-positive ECs in infected compared to noninfected groups [0.2942 % (interquartile ranges (IR), 0.2941; n¿=¿26) versus 0 % (IR, 0; n¿=¿12), p¿",
author = "Birck, {Malene Muusfeldt} and Antti Saraste and Poul Hyttel and Michal Odermarsky and Petru Liuba and Pekka Saukko and Hansen, {Axel Jacob Kornerup} and Erkki Pesonen",
year = "2013",
doi = "10.1007/s12265-013-9463-2",
language = "English",
volume = "6",
pages = "579--587",
journal = "Journal of Cardiovascular Translational Research",
issn = "1937-5387",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Endothelial cell death and intimal foam cell accumulation in the coronary artery of infected hypercholesterolemic minipigs

AU - Birck, Malene Muusfeldt

AU - Saraste, Antti

AU - Hyttel, Poul

AU - Odermarsky, Michal

AU - Liuba, Petru

AU - Saukko, Pekka

AU - Hansen, Axel Jacob Kornerup

AU - Pesonen, Erkki

PY - 2013

Y1 - 2013

N2 - Apoptosis of endothelial cells (ECs) has been suggested to play a role in atherosclerosis. We studied the synergism of hypercholesterolemia with Chlamydia pneumoniae and influenza virus infections on EC morphology and intimal changes in a minipig model. The coronary artery was excised at euthanasia (19 weeks of age) and serial sections were processed for the detection of EC apoptosis, histology, and transmission electron microscopy (TEM) studies. There was a significantly higher number of TUNEL-positive ECs in infected compared to noninfected groups [0.2942 % (interquartile ranges (IR), 0.2941; n¿=¿26) versus 0 % (IR, 0; n¿=¿12), p¿

AB - Apoptosis of endothelial cells (ECs) has been suggested to play a role in atherosclerosis. We studied the synergism of hypercholesterolemia with Chlamydia pneumoniae and influenza virus infections on EC morphology and intimal changes in a minipig model. The coronary artery was excised at euthanasia (19 weeks of age) and serial sections were processed for the detection of EC apoptosis, histology, and transmission electron microscopy (TEM) studies. There was a significantly higher number of TUNEL-positive ECs in infected compared to noninfected groups [0.2942 % (interquartile ranges (IR), 0.2941; n¿=¿26) versus 0 % (IR, 0; n¿=¿12), p¿

U2 - 10.1007/s12265-013-9463-2

DO - 10.1007/s12265-013-9463-2

M3 - Journal article

C2 - 23580230

VL - 6

SP - 579

EP - 587

JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

SN - 1937-5387

IS - 4

ER -

ID: 45708526