Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development: Evidence from experimental studies focused primarily on the rat

Research output: Contribution to journal › Review › Research › peer-review

Standard

Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development : Evidence from experimental studies focused primarily on the rat. / Jensen, Vivi F.H.; Mølck, Anne Marie; Lykkesfeldt, Jens; Bøgh, Ingrid B.

In: Reproductive Toxicology, Vol. 77, 04.2018, p. 1-24.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Jensen, VFH, Mølck, AM, Lykkesfeldt, J & Bøgh, IB 2018, 'Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development: Evidence from experimental studies focused primarily on the rat', Reproductive Toxicology, vol. 77, pp. 1-24. https://doi.org/10.1016/j.reprotox.2018.01.007

APA

Jensen, V. F. H., Mølck, A. M., Lykkesfeldt, J., & Bøgh, I. B. (2018). Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development: Evidence from experimental studies focused primarily on the rat. Reproductive Toxicology, 77, 1-24. https://doi.org/10.1016/j.reprotox.2018.01.007

Vancouver

Jensen VFH, Mølck AM, Lykkesfeldt J, Bøgh IB. Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development: Evidence from experimental studies focused primarily on the rat. Reproductive Toxicology. 2018 Apr;77:1-24. https://doi.org/10.1016/j.reprotox.2018.01.007

Author

Jensen, Vivi F.H. ; Mølck, Anne Marie ; Lykkesfeldt, Jens ; Bøgh, Ingrid B. / Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development : Evidence from experimental studies focused primarily on the rat. In: Reproductive Toxicology. 2018 ; Vol. 77. pp. 1-24.

Bibtex

@article{6ebe46a7f9b24963a32c106cdeed322c,
title = "Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development: Evidence from experimental studies focused primarily on the rat",
abstract = "Glucose is the major energy substrate during embryogenesis and the embryo is dependent on glucose from the maternal circulation to ensure normal metabolism and growth. The placenta plays a key role in this nutrient transfer in mammals, both during embryogenesis and after the development of the chorio-allantoic placental circulation. Maternal hypoglycaemia is accompanied by foetal hypoglycaemia and maternal counter-regulatory measures including a priority to keep nutrients in the maternal circulation by restricting their transfer to the foetus. Concomitantly, the foetus initiates its own counter-regulatory attempt to secure nutrients for its development and survival. Despite these measures, there is a general decrease in nutrient transfer to the foetus, which may have severe consequences for foetal development such as malformations and delayed skeletal development.",
keywords = "Fetal development, Gestation, Intra-uterine growth restriction, Malformations, Maternal hypoglycemia, Materno-foetal nutrient transfer, Skeletal development",
author = "Jensen, {Vivi F.H.} and M{\o}lck, {Anne Marie} and Jens Lykkesfeldt and B{\o}gh, {Ingrid B.}",
year = "2018",
month = apr,
doi = "10.1016/j.reprotox.2018.01.007",
language = "English",
volume = "77",
pages = "1--24",
journal = "Reproductive Toxicology",
issn = "0890-6238",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development

T2 - Evidence from experimental studies focused primarily on the rat

AU - Jensen, Vivi F.H.

AU - Mølck, Anne Marie

AU - Lykkesfeldt, Jens

AU - Bøgh, Ingrid B.

PY - 2018/4

Y1 - 2018/4

N2 - Glucose is the major energy substrate during embryogenesis and the embryo is dependent on glucose from the maternal circulation to ensure normal metabolism and growth. The placenta plays a key role in this nutrient transfer in mammals, both during embryogenesis and after the development of the chorio-allantoic placental circulation. Maternal hypoglycaemia is accompanied by foetal hypoglycaemia and maternal counter-regulatory measures including a priority to keep nutrients in the maternal circulation by restricting their transfer to the foetus. Concomitantly, the foetus initiates its own counter-regulatory attempt to secure nutrients for its development and survival. Despite these measures, there is a general decrease in nutrient transfer to the foetus, which may have severe consequences for foetal development such as malformations and delayed skeletal development.

AB - Glucose is the major energy substrate during embryogenesis and the embryo is dependent on glucose from the maternal circulation to ensure normal metabolism and growth. The placenta plays a key role in this nutrient transfer in mammals, both during embryogenesis and after the development of the chorio-allantoic placental circulation. Maternal hypoglycaemia is accompanied by foetal hypoglycaemia and maternal counter-regulatory measures including a priority to keep nutrients in the maternal circulation by restricting their transfer to the foetus. Concomitantly, the foetus initiates its own counter-regulatory attempt to secure nutrients for its development and survival. Despite these measures, there is a general decrease in nutrient transfer to the foetus, which may have severe consequences for foetal development such as malformations and delayed skeletal development.

KW - Fetal development

KW - Gestation

KW - Intra-uterine growth restriction

KW - Malformations

KW - Maternal hypoglycemia

KW - Materno-foetal nutrient transfer

KW - Skeletal development

U2 - 10.1016/j.reprotox.2018.01.007

DO - 10.1016/j.reprotox.2018.01.007

M3 - Review

C2 - 29408374

AN - SCOPUS:85041748155

VL - 77

SP - 1

EP - 24

JO - Reproductive Toxicology

JF - Reproductive Toxicology

SN - 0890-6238

ER -

ID: 194910173