Colonic lesions, cytokine profiles, and gut microbiota in plasminogen-deficient mice

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Colonic lesions, cytokine profiles, and gut microbiota in plasminogen-deficient mice. / Vestergaard, Bill; Krych, Lukasz; Lund, Leif R.; Jørgensen, Bettina Merete Pyndt; Hansen, Lars H.; Jensen, Henrik Elvang; Nielsen, Dennis Sandris; Hansen, Axel Kornerup.

In: Comparative Medicine, Vol. 65, No. 5, 2015, p. 382-397.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Vestergaard, B, Krych, L, Lund, LR, Jørgensen, BMP, Hansen, LH, Jensen, HE, Nielsen, DS & Hansen, AK 2015, 'Colonic lesions, cytokine profiles, and gut microbiota in plasminogen-deficient mice', Comparative Medicine, vol. 65, no. 5, pp. 382-397. <http://www.ingentaconnect.com/content/aalas/cm/2015/00000065/00000005/art00002>

APA

Vestergaard, B., Krych, L., Lund, L. R., Jørgensen, B. M. P., Hansen, L. H., Jensen, H. E., Nielsen, D. S., & Hansen, A. K. (2015). Colonic lesions, cytokine profiles, and gut microbiota in plasminogen-deficient mice. Comparative Medicine, 65(5), 382-397. http://www.ingentaconnect.com/content/aalas/cm/2015/00000065/00000005/art00002

Vancouver

Vestergaard B, Krych L, Lund LR, Jørgensen BMP, Hansen LH, Jensen HE et al. Colonic lesions, cytokine profiles, and gut microbiota in plasminogen-deficient mice. Comparative Medicine. 2015;65(5):382-397.

Author

Vestergaard, Bill ; Krych, Lukasz ; Lund, Leif R. ; Jørgensen, Bettina Merete Pyndt ; Hansen, Lars H. ; Jensen, Henrik Elvang ; Nielsen, Dennis Sandris ; Hansen, Axel Kornerup. / Colonic lesions, cytokine profiles, and gut microbiota in plasminogen-deficient mice. In: Comparative Medicine. 2015 ; Vol. 65, No. 5. pp. 382-397.

Bibtex

@article{e02a7026330c4692a704f41e8ed0e359,
title = "Colonic lesions, cytokine profiles, and gut microbiota in plasminogen-deficient mice",
abstract = "Plasminogen-deficient (FVB/NPan-plg(tm1Jld), plg(tm1Jld)) mice, which are widely used as a wound-healing model, are prone to spontaneous rectal prolapses. The aims of this study were 1) to evaluate the fecal microbiome of plg(tm1Jld) mice for features that might contribute to the development of rectal prolapses and colonic inflammation and 2) to assess the relevance of the inflammatory phenotype to the variability in wound healing in this model. The (plgtm1Jld) mice exhibited delayed wound healing, and they could be divided into 3 distinct groups that differed according to the time until wound closure. Colonic lesions in plg(tm1Jld) mice, which were characterized by necrotizing ulcerations and cystically dilated glands, were restricted to the intermediate and distal parts of the colon. The cytokine profile was indicative of chronic tissue damage, but the genetic modification did not change the composition of the gut microbiota, and none of the clinical or biochemical parameters correlated with the gut microbiota composition.",
author = "Bill Vestergaard and Lukasz Krych and Lund, {Leif R.} and J{\o}rgensen, {Bettina Merete Pyndt} and Hansen, {Lars H.} and Jensen, {Henrik Elvang} and Nielsen, {Dennis Sandris} and Hansen, {Axel Kornerup}",
year = "2015",
language = "English",
volume = "65",
pages = "382--397",
journal = "Comparative Medicine",
issn = "1532-0820",
publisher = "American Association for Laboratory Animal Science",
number = "5",

}

RIS

TY - JOUR

T1 - Colonic lesions, cytokine profiles, and gut microbiota in plasminogen-deficient mice

AU - Vestergaard, Bill

AU - Krych, Lukasz

AU - Lund, Leif R.

AU - Jørgensen, Bettina Merete Pyndt

AU - Hansen, Lars H.

AU - Jensen, Henrik Elvang

AU - Nielsen, Dennis Sandris

AU - Hansen, Axel Kornerup

PY - 2015

Y1 - 2015

N2 - Plasminogen-deficient (FVB/NPan-plg(tm1Jld), plg(tm1Jld)) mice, which are widely used as a wound-healing model, are prone to spontaneous rectal prolapses. The aims of this study were 1) to evaluate the fecal microbiome of plg(tm1Jld) mice for features that might contribute to the development of rectal prolapses and colonic inflammation and 2) to assess the relevance of the inflammatory phenotype to the variability in wound healing in this model. The (plgtm1Jld) mice exhibited delayed wound healing, and they could be divided into 3 distinct groups that differed according to the time until wound closure. Colonic lesions in plg(tm1Jld) mice, which were characterized by necrotizing ulcerations and cystically dilated glands, were restricted to the intermediate and distal parts of the colon. The cytokine profile was indicative of chronic tissue damage, but the genetic modification did not change the composition of the gut microbiota, and none of the clinical or biochemical parameters correlated with the gut microbiota composition.

AB - Plasminogen-deficient (FVB/NPan-plg(tm1Jld), plg(tm1Jld)) mice, which are widely used as a wound-healing model, are prone to spontaneous rectal prolapses. The aims of this study were 1) to evaluate the fecal microbiome of plg(tm1Jld) mice for features that might contribute to the development of rectal prolapses and colonic inflammation and 2) to assess the relevance of the inflammatory phenotype to the variability in wound healing in this model. The (plgtm1Jld) mice exhibited delayed wound healing, and they could be divided into 3 distinct groups that differed according to the time until wound closure. Colonic lesions in plg(tm1Jld) mice, which were characterized by necrotizing ulcerations and cystically dilated glands, were restricted to the intermediate and distal parts of the colon. The cytokine profile was indicative of chronic tissue damage, but the genetic modification did not change the composition of the gut microbiota, and none of the clinical or biochemical parameters correlated with the gut microbiota composition.

M3 - Journal article

C2 - 26473342

VL - 65

SP - 382

EP - 397

JO - Comparative Medicine

JF - Comparative Medicine

SN - 1532-0820

IS - 5

ER -

ID: 152244396