Animal Models of Fibrosis in Nonalcoholic Steatohepatitis: Do They Reflect Human Disease?

Research output: Contribution to journal › Review › Research › peer-review

Standard

Animal Models of Fibrosis in Nonalcoholic Steatohepatitis: Do They Reflect Human Disease? / Ipsen, David H; Lykkesfeldt, Jens; Tveden-nyborg, Pernille.

In: Advances in Nutrition, Vol. 11, No. 6, 2020, p. 1696–1711.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Ipsen, DH, Lykkesfeldt, J & Tveden-nyborg, P 2020, 'Animal Models of Fibrosis in Nonalcoholic Steatohepatitis: Do They Reflect Human Disease?', Advances in Nutrition, vol. 11, no. 6, pp. 1696–1711. https://doi.org/10.1093/advances/nmaa081

APA

Ipsen, D. H., Lykkesfeldt, J., & Tveden-nyborg, P. (2020). Animal Models of Fibrosis in Nonalcoholic Steatohepatitis: Do They Reflect Human Disease? Advances in Nutrition, 11(6), 1696–1711. https://doi.org/10.1093/advances/nmaa081

Vancouver

Ipsen DH, Lykkesfeldt J, Tveden-nyborg P. Animal Models of Fibrosis in Nonalcoholic Steatohepatitis: Do They Reflect Human Disease? Advances in Nutrition. 2020;11(6):1696–1711. https://doi.org/10.1093/advances/nmaa081

Author

Ipsen, David H ; Lykkesfeldt, Jens ; Tveden-nyborg, Pernille. / Animal Models of Fibrosis in Nonalcoholic Steatohepatitis: Do They Reflect Human Disease?. In: Advances in Nutrition. 2020 ; Vol. 11, No. 6. pp. 1696–1711.

Bibtex

@article{6adc5661581d4d41b773dc5f66f7daaa,
title = "Animal Models of Fibrosis in Nonalcoholic Steatohepatitis: Do They Reflect Human Disease?",
abstract = "Nonalcoholic steatohepatitis (NASH) is one of the most common chronic liver diseases in the world, yet no pharmacotherapies are available. The lack of translational animal models is a major barrier impeding elucidation of disease mechanisms and drug development. Multiple preclinical models of NASH have been proposed and can broadly be characterized as diet-induced, deficiency-induced, toxin-induced, genetically induced, or a combination of these. However, very few models develop advanced fibrosis while still reflecting human disease etiology or pathology, which is problematic since fibrosis stage is considered the best prognostic marker in patients and an important endpoint in clinical trials of NASH. While mice and rats predominate the NASH research, several other species have emerged as promising models. This review critically evaluates animal models of NASH, focusing on their ability to develop advanced fibrosis while maintaining their relevance to the human condition.",
author = "Ipsen, {David H} and Jens Lykkesfeldt and Pernille Tveden-nyborg",
year = "2020",
doi = "10.1093/advances/nmaa081",
language = "English",
volume = "11",
pages = "1696–1711",
journal = "Advances in Nutrition",
issn = "2161-8313",
publisher = "American Society for Nutrition",
number = "6",

}

RIS

TY - JOUR

T1 - Animal Models of Fibrosis in Nonalcoholic Steatohepatitis: Do They Reflect Human Disease?

AU - Ipsen, David H

AU - Lykkesfeldt, Jens

AU - Tveden-nyborg, Pernille

PY - 2020

Y1 - 2020

N2 - Nonalcoholic steatohepatitis (NASH) is one of the most common chronic liver diseases in the world, yet no pharmacotherapies are available. The lack of translational animal models is a major barrier impeding elucidation of disease mechanisms and drug development. Multiple preclinical models of NASH have been proposed and can broadly be characterized as diet-induced, deficiency-induced, toxin-induced, genetically induced, or a combination of these. However, very few models develop advanced fibrosis while still reflecting human disease etiology or pathology, which is problematic since fibrosis stage is considered the best prognostic marker in patients and an important endpoint in clinical trials of NASH. While mice and rats predominate the NASH research, several other species have emerged as promising models. This review critically evaluates animal models of NASH, focusing on their ability to develop advanced fibrosis while maintaining their relevance to the human condition.

AB - Nonalcoholic steatohepatitis (NASH) is one of the most common chronic liver diseases in the world, yet no pharmacotherapies are available. The lack of translational animal models is a major barrier impeding elucidation of disease mechanisms and drug development. Multiple preclinical models of NASH have been proposed and can broadly be characterized as diet-induced, deficiency-induced, toxin-induced, genetically induced, or a combination of these. However, very few models develop advanced fibrosis while still reflecting human disease etiology or pathology, which is problematic since fibrosis stage is considered the best prognostic marker in patients and an important endpoint in clinical trials of NASH. While mice and rats predominate the NASH research, several other species have emerged as promising models. This review critically evaluates animal models of NASH, focusing on their ability to develop advanced fibrosis while maintaining their relevance to the human condition.

U2 - 10.1093/advances/nmaa081

DO - 10.1093/advances/nmaa081

M3 - Review

C2 - 33191435

VL - 11

SP - 1696

EP - 1711

JO - Advances in Nutrition

JF - Advances in Nutrition

SN - 2161-8313

IS - 6

ER -

ID: 248555899