- 2020
- Published
Myocardial Changes in Diabetic and Nondiabetic Nonhuman Primates
Krog, S., Ludvigsen, Trine Pagh, Nielsen, O. L., Kirk, R. K., Lykkegaard, K., Wulff, E. M., Møller, J. E., Pedersen, H. D. & Olsen, Lisbeth Høier, 2020, In: Veterinary Pathology. 57, 2, p. 332-343 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
On the effect of vitamin C intake on human health: How to (mis)interprete the clinical evidence
Lykkesfeldt, Jens, 2020, In: Redox Biology. 34, 13 p., 101532.Research output: Contribution to journal › Review › Research › peer-review
- Published
Vitamin C pharmacokinetics*
Lykkesfeldt, Jens, 1 Jan 2020, Vitamin C: New Biochemical and Functional Insights. CRC Press, p. 55-70 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Proteoglycan synthesis rate as a novel method to measure blood-induced cartilage degeneration in non-haemophilic and haemophilic rats
Pulles, A. E., Vøls, Kåre Kryger, Christensen, K. R., Coeleveld, K., Hansen, Axel Kornerup, van Vulpen, L. F. D., Petersen, M., Mastbergen, S. C., Roepstorff, K., Schutgens, R. E. G., Kjelgaard-Hansen, M. & Lafeber, F. P. J. G., 2020, In: Haemophilia. 26, 3, p. e88-e96Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intermittent mitral regurgitation in Cavalier King Charles spaniels: Short-term progression and influence of stress tests
Reimann, Maria Josefine, Møller, J. E., Häggström, J., Åkerström, L. L. B., Martinussen, Torben & Olsen, Lisbeth Høier, 2020, In: Veterinary Journal. 258, 105457.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of insulin on natriuretic peptide gene expression in porcine heart
Terzic, D., Zois, N. E., Hunter, I., Christoffersen, Christina, Plomgaard, Peter Stendahl, Olsen, Lisbeth Høier, Jørgensen, Stine Ringholm, Pilegaard, Henriette & Goetze, Jens P. , 2020, In: Peptides. 131, 10 p., 170370.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TL1A regulates adipose-resident innate lymphoid immune responses and enables diet-induced obesity in mice
Tougaard, P., Martinsen, L. O., Lützhøft, Ditte Olsen, Jensen, Henrik Elvang, Flethøj, M., Vandenabeele, P., Pedersen, Anders Elm, Skov, Søren, Hansen, Axel Kornerup & Hansen, Camilla Hartmann Friis, 2020, In: International journal of obesity (2005). 44, p. 1062–1074Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vivo fluorescence molecular tomography of induced haemarthrosis in haemophilic mice: link between bleeding characteristics and development of bone pathology
Vøls, Kåre Kryger, Kjelgaard-Hansen, M., Ley, C. D., Hansen, Axel Kornerup & Petersen, M., 14 Apr 2020, In: BMC Musculoskeletal Disorders. 21, 1, 10 p., 241.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Initial joint bleed volume in a delayed on-demand treatment setup correlates with subsequent synovial changes in hemophilic mice
Vøls, Kåre Kryger, Kjelgaard-Hansen, M., Ley, C. D., Hansen, Axel Kornerup & Petersen, M., 2020, In: Animal models and experimental medicine. 3, 2, p. 160-168 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Central control of energy balance by amylin and calcitonin receptor agonists and their potential for treatment of metabolic diseases
Zakariassen, Hannah Louise, John, L. M. & Lutz, T. A., 2020, In: Basic & Clinical Pharmacology & Toxicology. 127, 3, p. 163-177Research output: Contribution to journal › Review › Research › peer-review
- Published
Salmon calcitonin distributes into the arcuate nucleus to a subset of NPY neurons in mice
Zakariassen, Hannah Louise, John, L. M., Lykkesfeldt, Jens, Raun, K., Glendorf, T., Schaffer, L., Lundh, S., Secher, A., Lutz, T. A. & Le Foll, C., 2020, In: Neuropharmacology. 167, 107987.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
An ELISA for detection of complement-bound circulating immune complexes in mice
Boysen, L., Lauritzen, B., Viuff, B. M., Lykkesfeldt, Jens & Landsy, L. H., 2019, In: Journal of Immunotoxicology. 16, 1, p. 82-86 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Formation and glomerular deposition of immune complexes in mice administered bovine serum albumin: Evaluation of dose, frequency, and biomarkers
Boysen, L., Viuff, B. M., Landsy, L. H., Price, S. A., Raymond, J. T., Lykkesfeldt, Jens & Lauritzen, B., 2019, In: Journal of Immunotoxicology. 16, 1, p. 191-200 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Generic immune complex assay for detection of murine anti-drug-antibodies in complex with human IgG
Boysen, L., Sprinkel, A. M. E., Lauritzen, B., Breinholt, J., Lykkesfeldt, Jens, Viuff, B. M. & Landsy, L. H., 2019, In: Biologicals. 60, p. 42-48 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peri-operative endothelial dysfunction in patients undergoing minor abdominal surgery: An observational study
Busch, S. V. E., Godthaab, C., Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Gögenur, I., Feb 2019, In: European Journal of Anaesthesiology. 36, 2, p. 130-134 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rapid inflammation and early degeneration of bone and cartilage revealed in a time-course study of induced haemarthrosis in haemophilic rats
Christensen, K. R., Kjelgaard-Hansen, M., Nielsen, Lise Nikolic, Wiinberg, B., Althoehn, F. A., Poulsen, N. B., Vøls, Kåre Kryger, Thyme, A. P., Lovgren, K. M., Hansen, Axel Kornerup & Roepstorff, K., 2019, In: Rheumatology. 58, 4, p. 588-599Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Urine 5-hydroxyindoleacetic acid in Cavalier King Charles spaniels with preclinical myxomatous mitral valve disease
Christiansen, L. B., Cremer, Signe Emilie, Helander, A., Madsen, T., Reimann, Maria Josefine, Møller, J. E., Höglund, K., Ljungvall, I., Häggström, J. & Olsen, Lisbeth Høier, 2019, In: Veterinary Journal. 250, p. 36-43 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antioxidant supplementation for lung disease in cystic fibrosis
Ciofu, Oana, Smith, S. & Lykkesfeldt, Jens, 2019, In: Cochrane Database of Systematic Reviews. 2019, 10, CD007020.Research output: Contribution to journal › Review › Research › peer-review
- Published
Effects of exercise and dietary protein sources on adiposity and insulin sensitivity in obese mice
Fjære, E., Myrmel, L. S., Lützhøft, Ditte Olsen, Andersen, H., Holm, J. B., Kiilerich, P., Hannisdal, R., Liaset, B., Kristiansen, Karsten & Madsen, L., 2019, In: Journal of Nutritional Biochemistry. 66, p. 98-109Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes
Gillberg, Linn, mxz703, mxz703, Nasif, A., Ohtani, H., Madaj, Z., Hansen, Jakob Werner, Rapin, N., Mogensen, J. B., Liu, M., Dufva, I. H., Lykkesfeldt, Jens, Hajkova, P., Jones, P. A. & Grønbæk, Kirsten, 17 Oct 2019, In: Clinical Epigenetics. 11, 1, p. 143-153 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Burrowing and nest building activity in mice after exposure to grid floor, isoflurane or ip injections
Gjendal, K., Ottesen, J. L., Olsson, I. A. S. & Sørensen, Dorte Bratbo, 1 Jul 2019, In: Physiology and Behavior. 206, p. 59-66 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Delayed insulin absorption correlates with alterations in subcutaneous depot kinetics in rats with diet‐induced obesity
Gradel, Anna Katrina Jógvansdóttir, Porsgaard, T., Brockhoff, P. M. B., Seested, T., Lykkesfeldt, Jens & Refsgaard, H. H. F., 2019, In: Obesity Science & Practice. 5, 3, p. 281-288Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular drivers of non-alcoholic steatohepatitis are sustained in mild-to-late fibrosis progression in a guinea pig model
Ipsen, David Højland, Skat-Rørdam, Josephine, Tsamouri, M. M., Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2019, In: Molecular Genetics and Genomics. 294, 3, p. 649–661Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Når leveren bliver for fed
Ipsen, David Højland, Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2019, In: Aktuel Naturvidenskab. 2019, 3, p. 28-31Research output: Contribution to journal › Journal article › Communication
- Published
Telomere length and genotoxicity in the lung of rats following intragastric exposure to food-grade titanium dioxide and vegetable carbon particles
Jensen, Ditte Marie, Løhr, M., Sheykhzade, Majid, Lykkesfeldt, Jens, Wils, Regitze Sølling, Loft, Steffen & Møller, Peter, 2019, In: Mutagenesis. 34, 2, p. 203-214 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glycemic control during pregnancy — A predictor of vitamin C status at labor in type 1 diabeticwomen?
Juhl, B., Lauszus, F. F. & Lykkesfeldt, Jens, 2019, In: Antioxidants. 8, 6, 153.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oral LPS Dosing Induces Local Immunological Changes in the Pancreatic Lymph Nodes in Mice
Kihl, Pernille, Krych, Lukasz, Deng, Ling, Kildemoes, A. O., Laigaard, A., Hansen, L. H., Hansen, Camilla Hartmann Friis, Buschard, K., Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2019, In: Journal of Diabetes Research. 2019, 9 p., 1649279.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Atorvastatin and vitamin e accelerates NASH resolution by dietary intervention in a preclinical guinea pig model
Klaebel, J. H., Skjødt, M., Skat-Rørdam, Josephine, Rakipovski, G., Ipsen, David Højland, Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2019, In: Nutrients. 11, 11, 20 p., 2834.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analytical validation of a conventional cardiac troponin I assay for dogs and cats
Langhorn, Rebecca, Yrfelt, J. D., Stjernegaard, C. S., Christiansen, L. B., Olsen, Lisbeth Høier & Nielsen, Lise Nikolic, 2019, In: Veterinary Clinical Pathology. p. 36-41Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dietary LPS traces influences disease expression of the diet-induced obese mouse
Lindenberg, F. C. B., Ellekilde, M., Thörn, A. C., Kihl, Pernille, Larsen, C. S., Hansen, Camilla Hartmann Friis, Metzdorff, S. B., Aalbæk, Bent & Hansen, Axel Kornerup, 2019, In: Research in Veterinary Science. 123, p. 195-203 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
18F-FDG PET/MR-imaging in a Göttingen Minipig model of atherosclerosis: Correlations with histology and quantitative gene expression
Ludvigsen, T. P., Pedersen, S. F., Vegge, A., Ripa, Rasmus Sejersten, Johannesen, H. H., Hansen, Adam Espe, Löfgren, J., Schumacher-Petersen, Camilla, Kirk, R. K., Pedersen, H. D., Christoffersen, B. Ø., Ørbæk, M., Forman, Julie Lyng, Klausen, T. L., Olsen, Lisbeth Høier & Kjær, Andreas, 2019, In: Atherosclerosis. 285, p. 55-63 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hyperglycemia-induced transcriptional regulation of ROCK1 and TGM2 expression is involved in small artery remodeling in obese diabetic Göttingen Minipigs
Ludvigsen, T. P., Olsen, Lisbeth Høier, Pedersen, H. D., Østergaard Christoffersen, B. & Jensen, Lars Jørn, 2019, In: Clinical Science. 133, 24, p. 2499–2516 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Pharmacokinetics of Vitamin C
Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2019, In: Nutrients. 11, 10, 20 p., 2412.Research output: Contribution to journal › Review › Research › peer-review
- Published
Short communication: Gut microbial colonization of the mouse colon using faecal transfer was equally effective when comparing rectal inoculation and oral inoculation based on 16S rRNA sequencing
Lützhøft, Ditte Olsen, Sánchez-Alcoholado, L., Tougaard, P., Mentzel, Caroline M. Junker, Kot, Witold, Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2019, In: Research in Veterinary Science. 126, p. 227-232 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Myxømatøs mitralklapsygdom hos hund: Metoder til diagnostik af behandlingskrævende sygdomsstadier
Reimann, Maria Josefine, Christiansen, L. B., Falk, T. & Olsen, Lisbeth Høier, 2019, In: Dansk Veterinaertidsskrift. 2019, 9, p. 28-32Research output: Contribution to journal › Review › Research › peer-review
- Published
Myxømatøs mitralklapsygdom hos hund: Medicinsk behandling
Reimann, Maria Josefine, Christiansen, L. B., Falk, B. T. & Olsen, Lisbeth Høier, 2019, In: Dansk Veterinaertidsskrift. 2019, 11, p. 38-43Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Determination of reduced and oxidized coenzyme Q10 in canine plasma and heart tissue by HPLC-ECD: Comparison with LC-MS/MS quantification
Schou-Pedersen, A. M. V., Schemeth, D. & Lykkesfeldt, Jens, 2019, In: Antioxidants. 8, 8, 253.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: Consequences of high fat-fructose-cholesterol diet and diabetes
Schumacher-Petersen, Camilla, Christoffersen, B. O., Kirk, R. K., Ludvigsen, T. P., Zois, N. E., Pedersen, H. D., Vyberg, M. & Olsen, Lisbeth Høier, 2019, In: Journal of Translational Medicine. 17, 1, 110.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A role of peroxisome proliferator-activated receptor gamma in non-alcoholic fatty liver disease
Skat-Rørdam, Josephine, Ipsen, David Højland, Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, May 2019, In: Basic & Clinical Pharmacology & Toxicology. 124, 5, p. 528-537Research output: Contribution to journal › Review › Research › peer-review
- Published
Expression of endothelin type B receptors in uterine artery smooth muscle cells from pregnant Guinea pigs
Skovsted, Gry Freja, Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, 2019, In: Placenta. 77, p. 8-15 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bleed volume of experimental knee haemarthrosis correlates with the subsequent degree of haemophilic arthropathy
Vøls, Kåre Kryger, Kjelgaard-Hansen, M., Ley, C. D., Hansen, Axel Kornerup & Petersen, M., 2019, In: Haemophilia. 25, 2, p. 324-333 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of melatonin on endothelial dysfunction in patients after acute coronary syndrome: The MEFACS randomized clinical trial
Zahid, J. A., Isbrand, A., Kleif, J., Schou-Pedersen, A. V., Lykkesfeldt, Jens, Madsen, M. T. & Gögenur, Ismail, 2019, In: Journal of Pineal Research. 67, 3, e12600.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Reduced early life mucosal integrity decreases thymic cell counts and increases local, but not thymic regulatory, T cell recruitment: Gut mucosal integrity breach and thymic T cells
Zakariassen, Hannah Louise, Bendtsen, K. M., Tougaard, P. & Hansen, Axel Kornerup, 2019, In: European Journal of Inflammation. 17, p. 1-16Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cross-species reactive monoclonal antibodies against the extracellular domains of the insulin receptor and IGF1 receptor
Ørstrup, Laura Kofoed Hvidsten, Slaaby, R., Rasch, M. G., Rasmussen, N., Lund, S., Brandt, J., Schluckebier, G., Wang, Z., Lützen, A., Pedersen, T. Å., Hvid, H., Hansen, B. F. & Blume, N., 2019, In: Journal of Immunological Methods. 465, p. 20-26 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Towards a Göttingen minipig model of adult onset growth hormone deficiency: evaluation of stereotactic electrocoagulation method
Ørstrup, Laura Kofoed Hvidsten, Tvilling, L., Orlowski, D., Zaer, H., Bjarkam, C. R., von Voss, P., Andersen, P. S., Christoffersen, B., Hedemann Sørensen, J. C., Laursen, T., Thygesen, P., Lykkesfeldt, Jens & Glud, A. N., 2019, In: Heliyon. 5, 11, 8 p., e02892.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Dietary normalization from a fat, fructose and cholesterol-rich diet to chow limits the amount of myocardial collagen in a Göttingen Minipig model of obesity
Andreasen, L. J., Krog, S., Ludvigsen, T. P., Nielsen, O. L., Møller, J. E., Christoffersen, B. Ø., Pedersen, H. D. & Olsen, Lisbeth Høier, 2018, In: Nutrition and Metabolism. 15, 64.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An Early Life Mucosal Insult Temporarily Decreases Acute Oxazolone-Induced Inflammation in Mice
Bendtsen, K. M., Tougaard, P. & Hansen, Axel Kornerup, 2018, In: Inflammation. 41, 4, p. 1437-1447 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The impact of exercise training and resveratrol supplementation on gut microbiota composition in high-fat diet fed mice
Brandt, N., Kotowska, D., Kristensen, C. M., Olesen, J., Lützhøft, Ditte Olsen, Halling, Jens Frey, Hansen, M., Al-Soud, W. A., Hansen, Lars Hestbjerg, Kiilerich, P. & Pilegaard, Henriette, 2018, In: Physiological Reports. 6, 20, p. 1-11 e13881.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gut microbiota recovery and immune response in ampicillin-treated mice
Castro Mejia, J. L., Jakesevic, M., Fabricius, N. F., Krych, Lukasz, Nielsen, Dennis Sandris, Kot, W., Bendtsen, K. M. B., Vogensen, Finn Kvist, Hansen, Camilla Hartmann Friis & Hansen, Axel Kornerup, 2018, In: Research in Veterinary Science. 118, p. 357-364 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SK channel inhibition did not increase short-term variability of the QT intervals in atrial tachypaced pigs with left ventricular dysfunction in contrast to the positive control dofetilide
Citerni, C., Kirchhoff, J., Olsen, Lisbeth Høier, Gentilini, F., Forni, M., Zannoni, A., Edvardsson, N., Bentzen, B., Grunnet, M. & Diness, J., 2018, In: European Heart Journal. 39, S1, p. 809-809 P3811.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Biodistribution of rhodamine B fluorescence-labeled cationic nanoparticles in rats
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Increased systemic oxidatively generated DNA and RNA damage in schizophrenia
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Does vitamin C enhance nitric oxide bioavailability in a tetrahydrobiopterin-dependent manner? In vitro, in vivo and clinical studies
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