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  1. 2018
  2. Published

    Long-term Western diet fed apolipoprotein E-deficient rats exhibit only modest early atherosclerotic characteristics

    Rune, Ida, Rolin, B., Lykkesfeldt, Jens, Nielsen, Dennis Sandris, Krych, Lukasz, Kanter, J. E., Bornfeldt, K. E., Kihl, Pernille, Buschard, K., Josefsen, K., Fels, J. J., Mortensen, A., Christoffersen, B., Kirk, R. K. & Hansen, Axel Kornerup, 2018, In: Scientific Reports. 8, 1, 12 p., 5416.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

    Ipsen, David Højland, Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2018, In: Cellular and Molecular Life Sciences. 75, 18, p. 3313-3327 15 p.

    Research output: Contribution to journal › Review › Research › peer-review

  4. Published

    Oral insulin does not alter gut microbiota composition of NOD mice

    Kihl, Pernille, Krych, Lukasz, Buschard, K., Wesley, J. D., Kot, W., Hansen, Axel Kornerup, Nielsen, Dennis Sandris & von Herrath, M. G., 2018, In: Diabetes/Metabolism Research and Reviews. 34, 6, 9 p., e3010.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Role of pannexin and adenosine triphosphate (ATP) following myocardial ischemia/reperfusion

    Kristiansen, S. B., Skovsted, Gry Freja, Berchtold, L. A., Radziwon-Balicka, A., Dreisig, K., Edvinsson, L., Sheykhzade, Majid & Haanes, Kristian Agmund, 2018, In: Scandinavian Cardiovascular Journal. 52, 6, p. 340-343

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    SK channel inhibition did not increase short-term variability of the QT intervals in atrial tachypaced pigs with left ventricular dysfunction in contrast to the positive control dofetilide

    Citerni, C., Kirchhoff, J., Olsen, Lisbeth Høier, Gentilini, F., Forni, M., Zannoni, A., Edvardsson, N., Bentzen, B., Grunnet, M. & Diness, J., 2018, In: European Heart Journal. 39, S1, p. 809-809 P3811.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  7. Published

    Spatial Memory Dysfunction Induced by Vitamin C Deficiency Is Associated with Changes in Monoaminergic Neurotransmitters and Aberrant Synapse Formation

    Hansen, S. N., Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2018, In: Antioxidants. 7, 7, p. 11 82.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development

    Rasmussen, K. K., Skat-Rørdam, Josephine, Andersen, P., Warzecha, C. B., Pye, M., Andersen, T. A., Ajbro, K. D., Bendsen, E., Narimatsu, M., Vilhardt, Frederik, Pedersen, Lotte Bang, Wrana, J. L., Anderson, R. H., Møllgård, Kjeld, Christensen, Søren Tvorup & Larsen, Lars Allan, 2018, In: Scientific Reports. 8, 1, 14 p., 9542.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    The impact of exercise training and resveratrol supplementation on gut microbiota composition in high-fat diet fed mice

    Brandt, N., Kotowska, D., Kristensen, C. M., Olesen, J., Lützhøft, Ditte Olsen, Halling, Jens Frey, Hansen, M., Al-Soud, W. A., Hansen, Lars Hestbjerg, Kiilerich, P. & Pilegaard, Henriette, 2018, In: Physiological Reports. 6, 20, p. 1-11 e13881.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide

    Jensen, Ditte Marie, Skovsted, Gry Freja, Lykkesfeldt, Jens, Dreier, R., Berg, J. O., Jeppesen, J. L., Sheykhzade, Majid, Loft, Steffen & Møller, Peter, 2018, In: Food and Chemical Toxicology. 120, p. 321-327 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Proximal Neuropathy and Associated Skeletal Muscle Changes Resembling Denervation Atrophy in Hindlimbs of Chronic Hypoglycaemic Rats

    Jensen, Vivi Flou Hjorth, Molck, A. M., Soeborg, H., Nowak, J., Chapman, M., Lykkesfeldt, Jens & Bogh, I. B., Jan 2018, In: Basic & Clinical Pharmacology & Toxicology. 122, 1, p. 165-175

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Symmetric Dimethylarginine in Cats with Hypertrophic Cardiomyopathy and Diabetes Mellitus

    Langhorn, Rebecca, Kieler, Ida Nordang, Koch, Jørgen, Christiansen, L. B. & Jessen, Lisbeth Rem, Jan 2018, In: Journal of Veterinary Internal Medicine. 32, 1, p. 57-63 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Comparison of Three Sample Preparation Procedures for the Quantification of L-Arginine, Asymmetric Dimethylarginine, and Symmetric Dimethylarginine in Human Plasma Using HPLC-FLD

    Schou-Pedersen, A. M. V. & Lykkesfeldt, Jens, 1 Feb 2018, In: Journal of Analytical Methods in Chemistry. 2018, 7 p., 6148515.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Vasomotor function in rat arteries after ex vivo and intragastric exposure to food-grade titanium dioxide and vegetable carbon particles

    Jensen, Ditte Marie, Christophersen, D. V., Sheykhzade, Majid, Skovsted, Gry Freja, Lykkesfeldt, Jens, Münter, R., Roursgaard, Martin, Loft, Steffen & Møller, Peter, 26 Feb 2018, In: Particle and Fibre Toxicology. 15, p. 1-18 12.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Long-term diet-induced hypertension in rats is associated with reduced expression and function of small artery SKCa, IKCa, and Kir2.1 channels

    Gradel, Anna Katrina Jógvansdóttir, Salomonsson, M., Sorensen, Charlotte Mehlin, von Holstein-Rathlou, Niels-Henrik & Jensen, Lars Jørn, 28 Feb 2018, In: Clinical Science. 132, 4, p. 461–474 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development: Evidence from experimental studies focused primarily on the rat

    Jensen, Vivi Flou Hjorth, Mølck, A. M., Lykkesfeldt, Jens & Bøgh, I. B., Apr 2018, In: Reproductive Toxicology. 77, p. 1-24 24 p.

    Research output: Contribution to journal › Review › Research › peer-review

  17. Published

    Expression of endothelin type B receptors (EDNRB) on smooth muscle cells is controlled by ternary complex factors and the actin cytoskeleton

    Krawczyk, K. K., Skovsted, Gry Freja, Perisic, L., Rippe, C., Dreier, R., Berg, J. O., Lykkesfeldt, Jens, Hedin, U. & Sward, K., Apr 2018.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  18. Published

    Evaluating IL-21 as a Potential Therapeutic Target in Crohn's Disease

    Lindebo Holm, T., Tornehave, D., Søndergaard, H., Kvist, P. H., Sondergaard, B., Hansen, L., Hermit, M. B., Holgersen, Kristine, Vergo , S., Frederiksen , K. S., Haase, C. & Lundsgaard, D., 10 Apr 2018, In: Gastroenterology Research and Practice. 2018, 22 p., 5962624.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Analytical validation of a flow cytometric protocol for quantification of platelet microparticles in dogs

    Cremer, Signe Emilie, Krogh, Anne Kirstine Havnsøe, Hedström, M. E. K., Christiansen, L. B., Tarnow, I. & Kristensen, Annemarie T., Jun 2018, In: Veterinary Clinical Pathology. 47, 2, p. 186-196 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Structural remodeling in cerebral and mesenteric arteries from obese Göttingen minipigs with or without diabetes

    Ludvigsen, Trine Pagh, Olsen, Lisbeth Høier, Pedersen, H. D., Østergaard Christoffersen, B. & Jensen, Lars Jørn, 13 Sep 2018, p. 467P-468P . 2 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  21. Published

    Cardiac procholecystokinin expression during haemodynamic changes in the mammalian heart

    Goetze, Jens P. , Hunter, I., Zois, N. E., Terzic, D., Valeur, N., Olsen, Lisbeth Høier, Smith, J., Plomgaard, Peter Stendahl, Hansen, L. H., Rehfeld, Jens Frederik, Balling, L. & Gustafsson, Finn, Oct 2018, In: Peptides. 108, p. 7-13 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. 2019
  23. Published

    18F-FDG PET/MR-imaging in a Göttingen Minipig model of atherosclerosis: Correlations with histology and quantitative gene expression

    Ludvigsen, T. P., Pedersen, S. F., Vegge, A., Ripa, Rasmus Sejersten, Johannesen, H. H., Hansen, Adam Espe, Löfgren, J., Schumacher-Petersen, Camilla, Kirk, R. K., Pedersen, H. D., Christoffersen, B. Ø., Ørbæk, M., Forman, Julie Lyng, Klausen, T. L., Olsen, Lisbeth Høier & Kjær, Andreas, 2019, In: Atherosclerosis. 285, p. 55-63 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    An ELISA for detection of complement-bound circulating immune complexes in mice

    Boysen, L., Lauritzen, B., Viuff, B. M., Lykkesfeldt, Jens & Landsy, L. H., 2019, In: Journal of Immunotoxicology. 16, 1, p. 82-86 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Analytical validation of a conventional cardiac troponin I assay for dogs and cats

    Langhorn, Rebecca, Yrfelt, J. D., Stjernegaard, C. S., Christiansen, L. B., Olsen, Lisbeth Høier & Nielsen, Lise Nikolic, 2019, In: Veterinary Clinical Pathology. p. 36-41

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Antioxidant supplementation for lung disease in cystic fibrosis

    Ciofu, Oana, Smith, S. & Lykkesfeldt, Jens, 2019, In: Cochrane Database of Systematic Reviews. 2019, 10, CD007020.

    Research output: Contribution to journal › Review › Research › peer-review

  27. Published

    Atorvastatin and vitamin e accelerates NASH resolution by dietary intervention in a preclinical guinea pig model

    Klaebel, J. H., Skjødt, M., Skat-Rørdam, Josephine, Rakipovski, G., Ipsen, David Højland, Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2019, In: Nutrients. 11, 11, 20 p., 2834.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Bleed volume of experimental knee haemarthrosis correlates with the subsequent degree of haemophilic arthropathy

    Vøls, Kåre Kryger, Kjelgaard-Hansen, M., Ley, C. D., Hansen, Axel Kornerup & Petersen, M., 2019, In: Haemophilia. 25, 2, p. 324-333 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Cross-species reactive monoclonal antibodies against the extracellular domains of the insulin receptor and IGF1 receptor

    Ørstrup, Laura Kofoed Hvidsten, Slaaby, R., Rasch, M. G., Rasmussen, N., Lund, S., Brandt, J., Schluckebier, G., Wang, Z., Lützen, A., Pedersen, T. Å., Hvid, H., Hansen, B. F. & Blume, N., 2019, In: Journal of Immunological Methods. 465, p. 20-26 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Delayed insulin absorption correlates with alterations in subcutaneous depot kinetics in rats with diet‐induced obesity

    Gradel, Anna Katrina Jógvansdóttir, Porsgaard, T., Brockhoff, P. M. B., Seested, T., Lykkesfeldt, Jens & Refsgaard, H. H. F., 2019, In: Obesity Science & Practice. 5, 3, p. 281-288

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Determination of reduced and oxidized coenzyme Q10 in canine plasma and heart tissue by HPLC-ECD: Comparison with LC-MS/MS quantification

    Schou-Pedersen, A. M. V., Schemeth, D. & Lykkesfeldt, Jens, 2019, In: Antioxidants. 8, 8, 253.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Dietary LPS traces influences disease expression of the diet-induced obese mouse

    Lindenberg, F. C. B., Ellekilde, M., Thörn, A. C., Kihl, Pernille, Larsen, C. S., Hansen, Camilla Hartmann Friis, Metzdorff, S. B., Aalbæk, Bent & Hansen, Axel Kornerup, 2019, In: Research in Veterinary Science. 123, p. 195-203 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Effects of exercise and dietary protein sources on adiposity and insulin sensitivity in obese mice

    Fjære, E., Myrmel, L. S., Lützhøft, Ditte Olsen, Andersen, H., Holm, J. B., Kiilerich, P., Hannisdal, R., Liaset, B., Kristiansen, Karsten & Madsen, L., 2019, In: Journal of Nutritional Biochemistry. 66, p. 98-109

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: Consequences of high fat-fructose-cholesterol diet and diabetes

    Schumacher-Petersen, Camilla, Christoffersen, B. O., Kirk, R. K., Ludvigsen, T. P., Zois, N. E., Pedersen, H. D., Vyberg, M. & Olsen, Lisbeth Høier, 2019, In: Journal of Translational Medicine. 17, 1, 110.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Expression of endothelin type B receptors in uterine artery smooth muscle cells from pregnant Guinea pigs

    Skovsted, Gry Freja, Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, 2019, In: Placenta. 77, p. 8-15 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Formation and glomerular deposition of immune complexes in mice administered bovine serum albumin: Evaluation of dose, frequency, and biomarkers

    Boysen, L., Viuff, B. M., Landsy, L. H., Price, S. A., Raymond, J. T., Lykkesfeldt, Jens & Lauritzen, B., 2019, In: Journal of Immunotoxicology. 16, 1, p. 191-200 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Generic immune complex assay for detection of murine anti-drug-antibodies in complex with human IgG

    Boysen, L., Sprinkel, A. M. E., Lauritzen, B., Breinholt, J., Lykkesfeldt, Jens, Viuff, B. M. & Landsy, L. H., 2019, In: Biologicals. 60, p. 42-48 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Glycemic control during pregnancy — A predictor of vitamin C status at labor in type 1 diabeticwomen?

    Juhl, B., Lauszus, F. F. & Lykkesfeldt, Jens, 2019, In: Antioxidants. 8, 6, 153.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Hyperglycemia-induced transcriptional regulation of ROCK1 and TGM2 expression is involved in small artery remodeling in obese diabetic Göttingen Minipigs

    Ludvigsen, T. P., Olsen, Lisbeth Høier, Pedersen, H. D., Østergaard Christoffersen, B. & Jensen, Lars Jørn, 2019, In: Clinical Science. 133, 24, p. 2499–2516 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Molecular drivers of non-alcoholic steatohepatitis are sustained in mild-to-late fibrosis progression in a guinea pig model

    Ipsen, David Højland, Skat-Rørdam, Josephine, Tsamouri, M. M., Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2019, In: Molecular Genetics and Genomics. 294, 3, p. 649–661

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Myxømatøs mitralklapsygdom hos hund: Medicinsk behandling

    Reimann, Maria Josefine, Christiansen, L. B., Falk, B. T. & Olsen, Lisbeth Høier, 2019, In: Dansk Veterinaertidsskrift. 2019, 11, p. 38-43

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Myxømatøs mitralklapsygdom hos hund: Metoder til diagnostik af behandlingskrævende sygdomsstadier

    Reimann, Maria Josefine, Christiansen, L. B., Falk, T. & Olsen, Lisbeth Høier, 2019, In: Dansk Veterinaertidsskrift. 2019, 9, p. 28-32

    Research output: Contribution to journal › Review › Research › peer-review

  43. Published

    Når leveren bliver for fed

    Ipsen, David Højland, Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2019, In: Aktuel Naturvidenskab. 2019, 3, p. 28-31

    Research output: Contribution to journal › Journal article › Communication

  44. Published

    Oral LPS Dosing Induces Local Immunological Changes in the Pancreatic Lymph Nodes in Mice

    Kihl, Pernille, Krych, Lukasz, Deng, Ling, Kildemoes, A. O., Laigaard, A., Hansen, L. H., Hansen, Camilla Hartmann Friis, Buschard, K., Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2019, In: Journal of Diabetes Research. 2019, 9 p., 1649279.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Rapid inflammation and early degeneration of bone and cartilage revealed in a time-course study of induced haemarthrosis in haemophilic rats

    Christensen, K. R., Kjelgaard-Hansen, M., Nielsen, Lise Nikolic, Wiinberg, B., Althoehn, F. A., Poulsen, N. B., Vøls, Kåre Kryger, Thyme, A. P., Lovgren, K. M., Hansen, Axel Kornerup & Roepstorff, K., 2019, In: Rheumatology. 58, 4, p. 588-599

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Reduced early life mucosal integrity decreases thymic cell counts and increases local, but not thymic regulatory, T cell recruitment: Gut mucosal integrity breach and thymic T cells

    Zakariassen, Hannah Louise, Bendtsen, K. M., Tougaard, P. & Hansen, Axel Kornerup, 2019, In: European Journal of Inflammation. 17, p. 1-16

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Short communication: Gut microbial colonization of the mouse colon using faecal transfer was equally effective when comparing rectal inoculation and oral inoculation based on 16S rRNA sequencing

    Lützhøft, Ditte Olsen, Sánchez-Alcoholado, L., Tougaard, P., Mentzel, Caroline M. Junker, Kot, Witold, Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2019, In: Research in Veterinary Science. 126, p. 227-232 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Telomere length and genotoxicity in the lung of rats following intragastric exposure to food-grade titanium dioxide and vegetable carbon particles

    Jensen, Ditte Marie, Løhr, M., Sheykhzade, Majid, Lykkesfeldt, Jens, Wils, Regitze Sølling, Loft, Steffen & Møller, Peter, 2019, In: Mutagenesis. 34, 2, p. 203-214 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    The Pharmacokinetics of Vitamin C

    Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2019, In: Nutrients. 11, 10, 20 p., 2412.

    Research output: Contribution to journal › Review › Research › peer-review

  50. Published

    The effect of melatonin on endothelial dysfunction in patients after acute coronary syndrome: The MEFACS randomized clinical trial

    Zahid, J. A., Isbrand, A., Kleif, J., Schou-Pedersen, A. V., Lykkesfeldt, Jens, Madsen, M. T. & Gögenur, Ismail, 2019, In: Journal of Pineal Research. 67, 3, e12600.

    Research output: Contribution to journal › Letter › Research › peer-review

  51. Published

    Towards a Göttingen minipig model of adult onset growth hormone deficiency: evaluation of stereotactic electrocoagulation method

    Ørstrup, Laura Kofoed Hvidsten, Tvilling, L., Orlowski, D., Zaer, H., Bjarkam, C. R., von Voss, P., Andersen, P. S., Christoffersen, B., Hedemann Sørensen, J. C., Laursen, T., Thygesen, P., Lykkesfeldt, Jens & Glud, A. N., 2019, In: Heliyon. 5, 11, 8 p., e02892.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Urine 5-hydroxyindoleacetic acid in Cavalier King Charles spaniels with preclinical myxomatous mitral valve disease

    Christiansen, L. B., Cremer, Signe Emilie, Helander, A., Madsen, T., Reimann, Maria Josefine, Møller, J. E., Höglund, K., Ljungvall, I., Häggström, J. & Olsen, Lisbeth Høier, 2019, In: Veterinary Journal. 250, p. 36-43 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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