- 2021
- Published
BCPT policy for experimental and clinical studies
Tveden-Nyborg, Pernille, Bergmann, T. K., Jessen, N., Simonsen, U. & Lykkesfeldt, Jens, 2021, In: Basic & Clinical Pharmacology & Toxicology. 128, 1, p. 4-8Research output: Contribution to journal › Review › Research › peer-review
- Published
Co-bedding of Preterm Newborn Pigs Reduces Necrotizing Enterocolitis Incidence Independent of Vital Functions and Cortisol Levels
Brunse, Anders, Peng, Y., Li, Y., Lykkesfeldt, Jens & Sangild, Per Torp, 2021, In: Frontiers in Pediatrics. 9, 636638.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Collagen remodelling and plasma ascorbic acid levels in patients suspected of inherited bleeding disorders harbouring germline variants in collagen‐related genes
Fager Ferrari, M., Zetterberg, E., Rossing, Caroline Maria, Manon‐jensen, T., Pehrsson, M., Karsdal, M. A., Lykkesfeldt, Jens & Leinoe, E., 2021, In: Haemophilia. 27, 1, p. e69-e77Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Decreased expression of the GLP-1 receptor after segmental artery injury in mice
Bjørnholm, K. D., Povlsen, G. K., Ougaard, M. E., Pyke, C., Rakipovski, G., Tveden-Nyborg, Pernille, Lykkesfeldt, Jens & Skovsted, Gry Freja, 2021, In: The Journal of endocrinology. 248, 3, p. 289-301 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Depleted myocardial coenzyme Q10 in cavalier king charles spaniels with congestive heart failure due to myxomatous mitral valve disease
Christiansen, L. B., Reimann, Maria Josefine, Schou-Pedersen, A. M. V., Larsen, Steen, Lykkesfeldt, Jens & Olsen, Lisbeth Høier, 2021, In: Antioxidants. 10, 2, p. 1-13 13 p., 161.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diet-Dependent Changes of the DNA Methylome Using a Göttingen Minipig Model for Obesity
Feng, Y., Cirera, Susanna, Taşöz, E., Liu, Y., Olsen, Lisbeth Høier, Christoffersen, B. Ø., Pedersen, H. D., Ludvigsen, T. P., Kirk, R. K., Schumacher-Petersen, Camilla, Deng, Y., Fredholm, Merete & Gao, Fei, 2021, In: Frontiers in Genetics. 12, 632859.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential effects of dietary components on glucose intolerance and non‐alcoholic steatohepatitis
Skat-Rørdam, Josephine, Ipsen, David Højland, Hardam, P. D., Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2021, In: Nutrients. 13, 8, 2523.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discrepancies in global vitamin C recommendations: a review of RDA criteria and underlying health perspectives
Carr, A. C. & Lykkesfeldt, Jens, 2021, In: Critical Reviews in Food Science and Nutrition. 61, 5, p. 742-755 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Extracellular vesicles as drivers of non-alcoholic fatty liver disease: Small particles with big impact
Ipsen, David Højland & Tveden-Nyborg, Pernille, 2021, In: Biomedicines. 9, 1, p. 1-13 13 p., 93.Research output: Contribution to journal › Review › Research › peer-review
- Published
Food intake rather than blood glucose levels affects the pharmacokinetic profile of insulin aspart in pigs
Gradel, Anna Katrina Jógvansdóttir, Kildegaard, J., Porsgaard, T., Lykkesfeldt, Jens & Refsgaard, H. H. F., 2021, In: Basic & Clinical Pharmacology & Toxicology. 128, 6, p. 783-794Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- Published
Hyperinsulinaemic hypoglycaemia in non-anaesthetized Göttingen minipigs induces a counter-regulatory endocrine response and electrocardiographic changes
Lyhne, Mille Kronborg, Vegge, A., Povlsen, G. K., Slaaby, R., Kildegaard, J., Pedersen-Bjergaard, Ulrik & Olsen, Lisbeth Høier, 2021, In: Scientific Reports. 11, 11 p., 5983.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD
Jensen, Victoria Svop, Fledelius, C., Zachodnik, C., Damgaard, J., Nygaard, H., Tornqvist, K. S., Kirk, R. K., Viuff, B. M., Wulff, E. M., Lykkesfeldt, Jens & Hvid, H., 2021, In: Journal of Translational Medicine. 19, 1, 80.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Liraglutide treatment improves endothelial function in the Ldlr-/- mouse model of atherosclerosis, and affects genes involved in vascular remodelling and inflammation
Bjørnholm, K. D., Skovsted, Gry Freja, Mitgaard-Thomsen, A., Rakipovski, G., Tveden-Nyborg, Pernille, Lykkesfeldt, Jens & Povlsen, G. K., 2021, In: Basic & Clinical Pharmacology & Toxicology. 128, 1, p. 103-114Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modelling Nonalcoholic Steatohepatitis In Vivo—A Close Transcriptomic Similarity Supports the Guinea Pig Disease Model
Skat-Rørdam, Josephine, Ipsen, David Højland, Seemann, Ernst Stefan, Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2021, In: Biomedicines. 9, 9, 18 p., 1198.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Non-immunogenic Induced Pluripotent Stem Cells, a Promising Way Forward for Allogenic Transplantations for Neurological Disorders
Frederiksen, Henriette Reventlow S, Doehn, U., Tveden-Nyborg, Pernille & Freude, Kristine, 2021, In: Frontiers in Genome Editing. 2, 623717.Research output: Contribution to journal › Review › Research › peer-review
- Published
Polymorphisms in the serotonin transporter gene and circulating concentrations of neurotransmitters in Cavalier King Charles Spaniels with myxomatous mitral valve disease
Reimann, Maria Josefine, Fredholm, Merete, Cremer, Signe Emilie, Christiansen, L. B., Meurs, K. M., Møller, J. E., Häggström, J., Lykkesfeldt, Jens & Olsen, Lisbeth Høier, 2021, In: Journal of Veterinary Internal Medicine. 35, 6, p. 2596-2606Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tail vein transection bleeding model in fully anesthetized hemophilia A mice
Carol Illa, Ariadna, Baumgarten, S., Danielsen, D., Larsen, K., Elm, T., Johansen, P. B., Knudsen, T., Lauritzen, B., Tranholm, M. & Ley, C. D., 2021, In: Journal of Visualized Experiments. 175, 17 p., e62952.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Temporal development of dyslipidemia and nonalcoholic fatty liver disease (Nafld) in syrian hamsters fed a high‐fat, high‐fructose, high‐cholesterol diet
Jensen, Victoria Svop, Fledelius, C., Wulff, E. M., Lykkesfeldt, Jens & Hvid, H., 2021, In: Nutrients. 13, 2, p. 1-18 18 p., 604.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The development of nonalcoholic steatohepatitis is subjected to breeder dependent variation in guinea pigs
Ipsen, David Højland, Agerskov, R. H., Klaebel, J. H., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2021, In: Scientific Reports. 11, 2955.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of acetylsalicylic acid and pentoxifylline in guinea pigs with non-alcoholic steatohepatitis
Ipsen, David Højland, Skat-Rørdam, Josephine, Svenningsen, M., Andersen, Mia Trein, Latta, M., Buelund, Lene Elisabeth, Lintrup, K., Skaarup, R., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2021, In: Basic & Clinical Pharmacology & Toxicology. 128, 4, p. 583-593Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The genetic consequences of dog breed formation - Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels: [+ correction]
Axelsson, E., Ljungvall, I., Bhoumik, P., Conn, L. B., Muren, E., Ohlsson, Å., Olsen, L. H., Engdahl, K., Hagman, R., Hanson, J., Kryvokhyzha, D., Pettersson, M., Grenet, O., Moggs, J., Del Rio-Espinola, A., Epe, C., Taillon, B., Tawari, N., Mane, S., Hawkins, T. & 4 others, , 2021, In: PLOS Genetics. 17, 9, 34 p., e1009726.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of vitamin C in epigenetic cancer therapy
Mikkelsen, Stine Ulrik, Gillberg, Linn, Lykkesfeldt, Jens & Grønbæk, Kirsten, 2021, In: Free Radical Biology and Medicine. 170, p. 179-193 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vitamin C: From Bench to Bedside
Carr, A. C. & Lykkesfeldt, Jens, 2021, In: Nutrients. 13, 4, 3 p., 1102.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
[68Ga]Ga-NODAGA-E[(cRGDyK)]2 Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction
Bentsen, Simon, Clemmensen, Andreas Høeg, Loft, Mathias Hougaard, Flethøj, M., Debes, Karina Poulsdóttir, Ludvigsen, Trine Pagh, Larsen, C. B., Kirchhoff, J., Olsen, Lisbeth Høier, Møller, J. E., Andersen, Thomas Lund, Johannesen, Helle Hjorth, Jespersen, Thomas & Kjær, Andreas, 2021, In: Diagnostics. 11, 10, 1807.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
The counterregulatory response to hypoglycaemia in the pig
Gradel, Anna Katrina Jógvansdóttir, Kildegaard, J., Ludvigsen, T. P., Porsgaard, T., Schou-Pedersen, A. M. V., Fels, J. J., Lykkesfeldt, Jens & Refsgaard, H. H. F., Oct 2020, In: Basic & Clinical Pharmacology & Toxicology. 127, 4, p. 278-286Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparison of sublingual, facial and retro-bulbar blood sampling in mice in relation to animal welfare and blood quality
Gjendal, K., Kiersgaard, M. K., Abelson, Klas, Sørensen, Dorte Bratbo & Ottesen, J. L., 1 May 2020, In: Journal of Pharmacological and Toxicological Methods. 103, 106680.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vivo fluorescence molecular tomography of induced haemarthrosis in haemophilic mice: link between bleeding characteristics and development of bone pathology
Vøls, Kåre Kryger, Kjelgaard-Hansen, M., Ley, C. D., Hansen, Axel Kornerup & Petersen, M., 14 Apr 2020, In: BMC Musculoskeletal Disorders. 21, 1, 10 p., 241.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vitamin C pharmacokinetics*
Lykkesfeldt, Jens, 1 Jan 2020, Vitamin C: New Biochemical and Functional Insights. CRC Press, p. 55-70 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
A systematic Cochrane Review of antioxidant supplementation lung disease for cystic fibrosis
Ciofu, Oana, Smith, S. & Lykkesfeldt, Jens, 2020, In: Paediatric Respiratory Reviews. 33, p. 28-29Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Animal Models of Fibrosis in Nonalcoholic Steatohepatitis: Do They Reflect Human Disease?
Ipsen, David Højland, Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2020, In: Advances in Nutrition. 11, 6, p. 1696–1711Research output: Contribution to journal › Review › Research › peer-review
- Published
Ascorbate maintains a low plasma oxygen level
Injarabian, L., Scherlinger, M., Devin, A., Ransac, S., Lykkesfeldt, Jens & Marteyn, B. S., 2020, In: Scientific Reports. 10, 1, 6 p., 10659.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Betamethasone Treatment for Atopic Dermatitis in Gut Microbiota Transplanted Mice
Debes, Karina Poulsdóttir, Evdina, N. A., Laigaard, A., Larsen, J. M., Zachariassen, L. F., Hansen, Camilla Hartmann Friis & Hansen, Axel Kornerup, 2020, In: Comparative Medicine. 70, 1, p. 6-15 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cardiac adaptation in hibernating, free-ranging Scandinavian Brown Bears (Ursus arctos)
Jørgensen, P. G., Evans, A., Kindberg, J., Olsen, Lisbeth Høier, Galatius, S. & Fröbert, O., 2020, In: Scientific Reports. 10, 1, 9 p., 247.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Central control of energy balance by amylin and calcitonin receptor agonists and their potential for treatment of metabolic diseases
Zakariassen, Hannah Louise, John, L. M. & Lutz, T. A., 2020, In: Basic & Clinical Pharmacology & Toxicology. 127, 3, p. 163-177Research output: Contribution to journal › Review › Research › peer-review
- Published
Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing
Citerni, C., Kirchhoff, J., Olsen, Lisbeth Høier, Sattler, Stefan M, Gentilini, F., Forni, M., Zannoni, A., Grunnet, Morten, Edvardsson, N., Bentzen, Bo Hjorth & Diness, J. G., 2020, In: Frontiers in Veterinary Science. 7, 12 p., 179.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dietary Intervention Accelerates NASH Resolution Depending on Inflammatory Status with Minor Additive Effects on Hepatic Injury by Vitamin E Supplementation
Klaebel, J. H., Rakipovski, G., Andersen, B., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2020, In: Antioxidants. 9, 9, 808.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of Repeated Exposure to Isoflurane on Nest Building and Burrowing in Mice
Gjendal, K., Ottesen, J. L., Olsson, I. A. S. & Sørensen, Dorte Bratbo, 2020, In: Journal of the American Association for Laboratory Animal Science : JAALAS. 59, 1, p. 30-36 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of insulin on natriuretic peptide gene expression in porcine heart
Terzic, D., Zois, N. E., Hunter, I., Christoffersen, Christina, Plomgaard, Peter Stendahl, Olsen, Lisbeth Høier, Jørgensen, Stine Ringholm, Pilegaard, Henriette & Goetze, Jens P. , 2020, In: Peptides. 131, 10 p., 170370.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Endothelial dysfunction and myocardial injury after major emergency abdominal surgery: a prospective cohort study
Ekeloef, S., Oreskov, J. O., Falkenberg, A., Burcharth, J., Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Gögenur, Ismail, 2020, In: BMC Anesthesiology. 20, 9 p., 67.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fgf21 regulates hepatic metabolic pathways to improve steatosis and inflammation
Keinicke, H., Sun, G., Mentzel, Caroline M. Junker, Fredholm, Merete, John, L. M., Andersen, B., Raun, K. & Kjaergaard, M., 2020, In: Endocrine Connections. 9, 8, p. 755-768 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Formation and Glomerular Deposition of Immune Complexes in Mice Administered Human Antibodies: Evaluation of Dose, Frequency, and Biomarkers
Boysen, L., Viuff, B. M., Landsy, L. H., Lykkesfeldt, Jens, Raymond, J. T., Price, S. A., Pelzer, H. & Lauritzen, B., 2020, In: Toxicologic Pathology. 48, 4, p. 570-585 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypophosphatemic Hypovitaminosis D Induces Osteomalacia in the Adult Female Rat
Durup, D., Diaz-delCastillo, M., Morgenlykke, J., Jensen, Lars Thorbjørn, Frandsen, E., Abelson, Klas, Pedersen, L., Lykkesfeldt, Jens, Ding, M., Jørgensen, Niklas Rye, Syberg, S., Petersen, S. & Heegaard, Anne-Marie, 2020, In: Endocrinology. 161, 8, bqaa100.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Importance of gestational hypoglycaemia for foetal malformations and skeletal development in rats
Jensen, Vivi Flou Hjorth, Mølck, A. M., Lykkesfeldt, Jens, Fels, J. J., Andersen, L., Renaut, R., McGuigan, F., Åkesson, K. E. & Bøgh, I. B., 2020, In: Reproductive Toxicology. 91, p. 14-26 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of KCa2 and Kv11.1 Channels in Pigs With Left Ventricular Dysfunction
Citerni, C., Kirchhoff, J., Olsen, Lisbeth Høier, Sattler, Stefan M, Grunnet, Morten, Edvardsson, N., Bentzen, Bo Hjorth & Diness, J. G., 2020, In: Frontiers in Pharmacology. 11, 11 p., 556.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Initial joint bleed volume in a delayed on-demand treatment setup correlates with subsequent synovial changes in hemophilic mice
Vøls, Kåre Kryger, Kjelgaard-Hansen, M., Ley, C. D., Hansen, Axel Kornerup & Petersen, M., 2020, In: Animal models and experimental medicine. 3, 2, p. 160-168 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inner histopathologic changes and disproportionate zone volumes in foetal growth plates following gestational hypoglycaemia in rats
Jensen, Vivi Flou Hjorth, Mølck, A., Bøgh, I. B., Nowak, J., Viuff, B. M., Rasmussen, C. L. M., Voetmann, Louise Marie, Fels, J. J., Madsen, S. H., McGuigan, F. E., Tveden-Nyborg, Pernille, Lykkesfeldt, Jens & Akesson, K. E., 2020, In: Scientific Reports. 10, 1, 13 p., 5609.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes
Andreasen, L. J., Kirk, R. K., Fledelius, C., Yorek, M. A., Lykkesfeldt, Jens & Akerstrom, T., 2020, In: Journal of Diabetes Research. 2020, 13 p., 9626398.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intermittent mitral regurgitation in Cavalier King Charles spaniels: Short-term progression and influence of stress tests
Reimann, Maria Josefine, Møller, J. E., Häggström, J., Åkerström, L. L. B., Martinussen, Torben & Olsen, Lisbeth Høier, 2020, In: Veterinary Journal. 258, 105457.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Malnutrition predisposes to endotoxin-induced edema and impaired inflammatory response in parenterally fed piglets
Bæk, Ole, Fabiansen, C., Friis, Henrik, Ritz, C., Koch, Jørgen, Willesen, Jakob, Heegaard, P. M. H., Lykkesfeldt, Jens, Briend, A., Golden, M. H., Sangild, Per Torp & Thymann, Thomas, 2020, In: Journal of Parenteral and Enteral Nutrition. 44, 4, p. 668-676Research output: Contribution to journal › Journal article › Research › peer-review
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Biodistribution of rhodamine B fluorescence-labeled cationic nanoparticles in rats
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Increased systemic oxidatively generated DNA and RNA damage in schizophrenia
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Does vitamin C enhance nitric oxide bioavailability in a tetrahydrobiopterin-dependent manner? In vitro, in vivo and clinical studies
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