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  1. 2021
  2. Published

    Extracellular vesicles as drivers of non-alcoholic fatty liver disease: Small particles with big impact

    Ipsen, David Højland & Tveden-Nyborg, Pernille, 2021, In: Biomedicines. 9, 1, p. 1-13 13 p., 93.

    Research output: Contribution to journal › Review › Research › peer-review

  3. Published

    Food intake rather than blood glucose levels affects the pharmacokinetic profile of insulin aspart in pigs

    Gradel, Anna Katrina Jógvansdóttir, Kildegaard, J., Porsgaard, T., Lykkesfeldt, Jens & Refsgaard, H. H. F., 2021, In: Basic & Clinical Pharmacology & Toxicology. 128, 6, p. 783-794

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Hepatic Stellate Cell Activation and Inactivation in NASH-Fibrosis—Roles as Putative Treatment Targets?

    Zisser, Alexandra, Ipsen, David Højland & Tveden-Nyborg, Pernille, 2021, In: Biomedicines. 9, 4, 365.

    Research output: Contribution to journal › Review › Research › peer-review

  5. Published

    Hyperinsulinaemic hypoglycaemia in non-anaesthetized Göttingen minipigs induces a counter-regulatory endocrine response and electrocardiographic changes

    Lyhne, Mille Kronborg, Vegge, A., Povlsen, G. K., Slaaby, R., Kildegaard, J., Pedersen-Bjergaard, Ulrik & Olsen, Lisbeth Høier, 2021, In: Scientific Reports. 11, 11 p., 5983.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD

    Jensen, Victoria Svop, Fledelius, C., Zachodnik, C., Damgaard, J., Nygaard, H., Tornqvist, K. S., Kirk, R. K., Viuff, B. M., Wulff, E. M., Lykkesfeldt, Jens & Hvid, H., 2021, In: Journal of Translational Medicine. 19, 1, 80.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Liraglutide treatment improves endothelial function in the Ldlr-/- mouse model of atherosclerosis, and affects genes involved in vascular remodelling and inflammation

    Bjørnholm, K. D., Skovsted, Gry Freja, Mitgaard-Thomsen, A., Rakipovski, G., Tveden-Nyborg, Pernille, Lykkesfeldt, Jens & Povlsen, G. K., 2021, In: Basic & Clinical Pharmacology & Toxicology. 128, 1, p. 103-114

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Modelling Nonalcoholic Steatohepatitis In Vivo—A Close Transcriptomic Similarity Supports the Guinea Pig Disease Model

    Skat-Rørdam, Josephine, Ipsen, David Højland, Seemann, Ernst Stefan, Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2021, In: Biomedicines. 9, 9, 18 p., 1198.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Non-immunogenic Induced Pluripotent Stem Cells, a Promising Way Forward for Allogenic Transplantations for Neurological Disorders

    Frederiksen, Henriette Reventlow S, Doehn, U., Tveden-Nyborg, Pernille & Freude, Kristine, 2021, In: Frontiers in Genome Editing. 2, 623717.

    Research output: Contribution to journal › Review › Research › peer-review

  10. Published

    Polymorphisms in the serotonin transporter gene and circulating concentrations of neurotransmitters in Cavalier King Charles Spaniels with myxomatous mitral valve disease

    Reimann, Maria Josefine, Fredholm, Merete, Cremer, Signe Emilie, Christiansen, L. B., Meurs, K. M., Møller, J. E., Häggström, J., Lykkesfeldt, Jens & Olsen, Lisbeth Høier, 2021, In: Journal of Veterinary Internal Medicine. 35, 6, p. 2596-2606

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Tail vein transection bleeding model in fully anesthetized hemophilia A mice

    Carol Illa, Ariadna, Baumgarten, S., Danielsen, D., Larsen, K., Elm, T., Johansen, P. B., Knudsen, T., Lauritzen, B., Tranholm, M. & Ley, C. D., 2021, In: Journal of Visualized Experiments. 175, 17 p., e62952.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Temporal development of dyslipidemia and nonalcoholic fatty liver disease (Nafld) in syrian hamsters fed a high‐fat, high‐fructose, high‐cholesterol diet

    Jensen, Victoria Svop, Fledelius, C., Wulff, E. M., Lykkesfeldt, Jens & Hvid, H., 2021, In: Nutrients. 13, 2, p. 1-18 18 p., 604.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    The development of nonalcoholic steatohepatitis is subjected to breeder dependent variation in guinea pigs

    Ipsen, David Højland, Agerskov, R. H., Klaebel, J. H., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2021, In: Scientific Reports. 11, 2955.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    The effect of acetylsalicylic acid and pentoxifylline in guinea pigs with non-alcoholic steatohepatitis

    Ipsen, David Højland, Skat-Rørdam, Josephine, Svenningsen, M., Andersen, Mia Trein, Latta, M., Buelund, Lene Elisabeth, Lintrup, K., Skaarup, R., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2021, In: Basic & Clinical Pharmacology & Toxicology. 128, 4, p. 583-593

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    The genetic consequences of dog breed formation - Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels: [+ correction]

    Axelsson, E., Ljungvall, I., Bhoumik, P., Conn, L. B., Muren, E., Ohlsson, Å., Olsen, L. H., Engdahl, K., Hagman, R., Hanson, J., Kryvokhyzha, D., Pettersson, M., Grenet, O., Moggs, J., Del Rio-Espinola, A., Epe, C., Taillon, B., Tawari, N., Mane, S., Hawkins, T. & 4 others, Hedhammar, Å., Gruet, P., Häggström, J. & Lindblad-Toh, K., 2021, In: PLOS Genetics. 17, 9, 34 p., e1009726.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    The role of vitamin C in epigenetic cancer therapy

    Mikkelsen, Stine Ulrik, Gillberg, Linn, Lykkesfeldt, Jens & Grønbæk, Kirsten, 2021, In: Free Radical Biology and Medicine. 170, p. 179-193 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Vitamin C: From Bench to Bedside

    Carr, A. C. & Lykkesfeldt, Jens, 2021, In: Nutrients. 13, 4, 3 p., 1102.

    Research output: Contribution to journal › Editorial › Research › peer-review

  18. Published

    [68Ga]Ga-NODAGA-E[(cRGDyK)]2 Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction

    Bentsen, Simon, Clemmensen, Andreas Høeg, Loft, Mathias Hougaard, Flethøj, M., Debes, Karina Poulsdóttir, Ludvigsen, Trine Pagh, Larsen, C. B., Kirchhoff, J., Olsen, Lisbeth Høier, Møller, J. E., Andersen, Thomas Lund, Johannesen, Helle Hjorth, Jespersen, Thomas & Kjær, Andreas, 2021, In: Diagnostics. 11, 10, 1807.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Modelling nonalcoholic steatohepatitis in vivo—a close transcriptomic similarity supports the guinea pig disease model

    Skat-Rørdam, Josephine, Ipsen, David Højland, Seemann, Ernst Stefan, Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, Sep 2021, In: Biomedicines. 9, 9, 1198.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. 2022
  21. Published

    A long‐term energy‐rich diet increases prefrontal bdnf in sprague‐dawley rats

    Virtuoso, Alessandro, Tveden-Nyborg, Pernille, Schou‐pedersen, A. M. V., Lykkesfeldt, Jens, Müller, H. K., Elfving, B. & Sørensen, Dorte Bratbo, 2022, In: Nutrients. 14, 1, 126.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    A porcine model of subcutaneous Staphylococcus aureus infection: a pilot study

    Nielsen, O. L., Mellergaard, M., Frees, Dorte, Larsen, M. N., Skov, Søren, Olsen, Lisbeth Høier & Reimann, Maria Josefine, 2022, In: APMIS - Journal of Pathology, Microbiology and Immunology. 130, 7, p. 359-370

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    CTLA4-Ig prevents development of neutralizing antibody formation after continuous treatment with human FVIII in HA rats

    Øvlisen, Gabi Overgaard, Thygesen, P., Weldingh, K. N., Bloem, E., Skov, Søren, Almholt, K., Lövgren, K. M., Ley, C. D. & Holm, T. L., 2022, In: Haemophilia. 28, 4, p. 568-577

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Comparison of the neuromuscular effects of two infusion rates of rocuronium in anesthetized pigs

    Pedersen, Kamilla, Kruhøffer, L. L., Lykkesfeldt, Jens & Kousholt, B. S., 2022, In: Acta Veterinaria Scandinavica. 64, 38.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Effect of gluten-free diet and antibiotics on murine gut microbiota and immune response to tetanus vaccination

    Kihl, Pernille, Krych, Lukasz, Deng, Ling, Hansen, Lars Hestbjerg, Buschard, K., Skov, Søren, Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2022, In: Plos One. 17, 4, 21 p., e0266719.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Effect of the sodium-glucose cotransporter-2 inhibitor dapagliflozinon platelet aggregation response in Cavalier King Charles Spanielswith and without cardiac disease

    Speitzer, A., Øgelund, E., Reimann, Maria Josefine, Møller, J. E., Skovsted, G. F., Lyhne, Mille Kronborg, Verma, S., Ljungvall, I., Häggström, J. & Olsen, Lisbeth Høier, 2022, In: Journal of Veterinary Internal Medicine. 36, 6, p. 2473 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  27. Published

    Efficacy of fibroblast growth factor 21 in non-alcoholic fatty liver disease in guinea pigs

    Klaebel, J. H., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2022, In: Basic & Clinical Pharmacology & Toxicology. 130, 3, p. 385-393

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes

    Lyhne, Mille Kronborg, Debes, Karina Poulsdóttir, Helgogaard, T., Vegge, A., Kildegaard, J., Pedersen-Bjergaard, Ulrik & Olsen, Lisbeth Høier, 2022, In: Journal of Pharmacological and Toxicological Methods. 118, 107221.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Estimation of Vitamin C Intake Requirements Based on Body Weight: Implications for Obesity

    Carr, A. C., Block, G. & Lykkesfeldt, Jens, 2022, In: Nutrients. 14, 7, 8 p., 1460.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Implantation of telemetric blood pressure transmitters in Göttingen Minipigs: Validation of 24-h systemic blood pressure and heart rate monitoring and influence of anaesthesia

    Carlsen, M. F., Christoffersen, B. Ø., Lindgaard, R., Pedersen, H. D. & Olsen, Lisbeth Høier, 2022, In: Journal of Pharmacological and Toxicological Methods. 115, 107168.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    In vitro cell cultures of Brunner's glands from male mouse to study GLP-1 receptor function

    Voetmann, Louise Marie, Underwood, C. R., Rolin, B., Hansen, Axel Kornerup, Kirk, R. K., Pyke, C., Knudsen, L. B. & Frederiksen, K. S., 2022, In: American journal of physiology. Cell physiology. 322, 6, p. C1260-C1269

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Lower Vitamin C Levels Are Associated With Less Improvement in Negative Symptoms in Initially Antipsychotic-Naïve Patients With First-Episode Psychosis

    Myken, A. N., Ebdrup, Bjørn, Sørensen, M. E., Broberg, B. V., Skjerbæk, M. W., Glenthøj, Birte Yding, Lykkesfeldt, Jens & Nielsen, Mette Ødegaard, 2022, In: The international journal of neuropsychopharmacology. 25, 8, p. 613-618 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Marked gut microbiota dysbiosis and increased imidazole propionate are associated with a NASH Göttingen Minipig model

    Lützhøft, Ditte Olsen, Sinioja, T., Christoffersen, B., Jakobsen, Rasmus Riemer, Geng, Dawei, Ahmad, H. F. B., Straarup, E. M., Pedersen, K. M., Kot, Witold, Pedersen, H. D., Cirera, Susanna, Hyötyläinen, T., Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2022, In: BMC Microbiology. 22, 1, 287.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Optimization of pig models for translation of subcutaneous pharmacokinetics of therapeutic proteins: Liraglutide, insulin aspart and insulin detemir

    Pedersen, K., Gradel, Anna Katrina Jógvansdóttir, Ludvigsen, T. P., Christoffersen, B. Ø., Fuglsang-Damgaard, C. A., Bendtsen, K. M., Madsen, S. H., Manfé, V. & Refsgaard, H. H. F., 2022, In: Translational Research. 239, p. 71-84

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Prolonged insulin-induced hypoglycaemia reduces ß-cell activity rather than number in pancreatic islets in non-diabetic rats

    Jensen, Vivi Flou Hjorth, Mølck, A. M., Nowak, J., Fels, J. J., Lykkesfeldt, Jens & Bøgh, I. B., 2022, In: Scientific Reports. 12, 14113.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Semaglutide treatment attenuates vessel remodelling in ApoE−/− mice following vascular injury and blood flow perturbation

    Jensen, Ditte Marie, Skovsted, Gry Freja, Bonde, M. F. B., Bentzon, J. F., Rolin, B., Franck, G., Ougaard, M. K. E., Voetmann, Louise Marie, Bachmann, J. C., Uryga, A., Pyke, C., Kirk, R. K., Hvid, H., Knudsen, L. B., Lykkesfeldt, Jens & Nyberg, M., 2022, In: Atherosclerosis Plus. 49, p. 32-41 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    The G213D variant in Nav1.5 alters sodium current and causes an arrhythmogenic phenotype resulting in a multifocal ectopic Purkinje-related premature contraction phenotype in human-induced pluripotent stem cell-derived cardiomyocytes

    Callø, Kirstine, Geryk, M., Freude, Kristine, Treat, J. A., Vold, V. A., Frederiksen, Henriette Reventlow S, Broendberg, A. K., Frederiksen, T. C., Jensen, H. K. & Cordeiro, J. M., 2022, In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 24, 12, p. 2015–2027

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Vitamin C Deficiency Exacerbates Dysfunction of Atherosclerotic Coronary Arteries in Guinea Pigs Fed a High-Fat Diet

    Skovsted, Gry Freja, Skat-Rørdam, Josephine, Frøkiær, A. P., Jensen, Henrik Elvang, Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, 2022, In: Antioxidants. 11, 11, 2226.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Vitamin C deficiency may delay diet-induced NASH regression in the guinea pig

    Skat-Rørdam, Josephine, Pedersen, Kamilla, Skovsted, Gry Freja, Gregersen, I., Vangsgaard, S., Ipsen, David Højland, Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2022, In: Antioxidants. 11, 1, 69.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. 2023
  41. Published

    In vivo effect of rFVIII and rFVIIa in hemophilia A rats evaluated by the Tail Vein Transection Bleeding Model

    Stagaard, Rikke, Øvlisen, Gabi Overgaard, Klæbel, J. H., Danielsen, D., Lund, A., Elm, T. & Ley, C. D., 2023, In: Journal of Thrombosis and Haemostasis. 21, 5, p. 1189-1199 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Ascorbate deficiency increases progression of shigellosis in guinea pigs and mice infection models

    Skerniskyte, J., Mulet, C., André, A. C., Anderson, M. C., Injarabian, L., Buck, A., Prade, V. M., Sansonetti, P. J., Reibel-Foisset, S., Walch, A. K., Lebel, M., Lykkesfeldt, Jens & Marteyn, B. S., 2023, In: Gut Microbes. 15, 2, 18 p., 2271597.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    BCPT 2023 policy for experimental and clinical studies

    Tveden-Nyborg, Pernille, Bergmann, T. K., Jessen, N., Simonsen, U. & Lykkesfeldt, Jens, 2023, In: Basic and Clinical Pharmacology and Toxicology. 133, 4, p. 391-396

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Charting a new course: A vision for the future as editors-in-chief

    Simonsen, U. & Lykkesfeldt, Jens, 2023, In: Basic and Clinical Pharmacology and Toxicology. 133, 4, p. 390 1 p.

    Research output: Contribution to journal › Editorial › Research

  45. Published

    Dietary Long-Chain Fatty Acids Accelerate Metabolic Dysfunction in Guinea Pigs with Non-Alcoholic Steatohepatitis

    Pedersen, Kamilla, Ipsen, David Højland, Skat-Rørdam, Josephine, Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2023, In: Nutrients. 15, 2445.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Does Aging Affect Vitamin C Status Relative to Intake? Findings from NHANES 2017-2018

    Carr, A. C. & Lykkesfeldt, Jens, 2023, In: Nutrients. 15, 4, 10 p., 892.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Effect of Remote Ischaemic Preconditioning on Perioperative Endothelial Dysfunction in Non-Cardiac Surgery: A Randomised Clinical Trial

    Wahlstrøm, K. L., Hansen, H. F., Kvist, M., Burcharth, Jakob, Lykkesfeldt, Jens, Gögenur, Ismail & Ekeloef, S., 2023, In: Cells. 12, 6, 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Effects of two- and twelve-weeks sodium-glucose cotransporter 2 inhibition on DNA and RNA oxidation: two randomized, placebo-controlled trials

    Larsen, E. L., Andersen, A., Kjær, L. K., Eickhoff, M. K., Frimodt-Møller, M., Persson, F., Rossing, Peter, Lykkesfeldt, Jens, Knop, Filip Krag, Vilsbøll, Tina, Rungby, Jørgen & Poulsen, Henrik Enghusen, 2023, In: Free Radical Research. 57, 2, p. 140-151

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Factors Affecting the Vitamin C Dose-Concentration Relationship: Implications for Global Vitamin C Dietary Recommendations

    Carr, A. C. & Lykkesfeldt, Jens, 2023, In: Nutrients. 15, 7, 19 p., 1657.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Functional and morphological renal changes in a Göttingen Minipig model of obesity-related and diabetic nephropathy

    Christoffersen, B. Ø., Kristensen, C. A., Lindgaard, R., Kirk, R. K., Viuff, B. M., Kvist, P. H., Pedersen, H. D., Ludvigsen, T. P., Skovgaard, T., Fels, J. J., Martinussen, Torben, Christiansen, L. B., Cirera, Susanna & Olsen, Lisbeth Høier, 2023, In: Scientific Reports. 13, 13 p., 6017.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Generation of eight hiPSCs lines from two pathogenic variants in CACNA1A using the CRISPR-Cas9 gene editing technology

    Rivera-Sánchez, P., Søndergaard, L., Wathikthinnakon, Methi, B. D. Magnusson, H., Frederiksen, Henriette Reventlow S, Aabæk Hammer, F., Taleb, R., Christian Cassidy, C., Tranholm Bruun, M., Tümer, Asuman Zeynep, Holst, B., Brasch-Andersen, C., Møller, R., Freude, Kristine & Chandrasekaran, Abinaya, 2023, In: Stem Cell Research. 71, 103193.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Increased meal-induced neurotensin response predicts successful maintenance of weight loss: Data from a randomized controlled trial

    Brethvad, Annemette Overgaard, Zakariassen, Hannah Louise, Holt, Joachim, Lundgren, J. R., Jakobsen, A., Hartmann, Bolette, Lehmann, E. W., Kissow, Hannelouise, Holst, Jens Juul, Madsbad, Sten, Torekov, Signe Sørensen & Holst, Birgitte, 2023, In: Metabolism: Clinical and Experimental. 143, 8 p., 155534.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Influence of general anaesthesia on circulating biomarkers of glucose metabolism in pigs

    Christoffersen, B. Ø., Bundgaard, C. J., Hjøllund, K. R., Fels, J. J., Boll, K. K., Lyhne, Mille Kronborg & Olsen, Lisbeth Høier, 2023, In: Laboratory Animals. 57, 6, p. 650-663

    Research output: Contribution to journal › Journal article › Research › peer-review

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