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  1. Published

    Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs

    Tveden-Nyborg, Pernille, Vogt, L., Schjoldager, J. G., Jeannet, N., Andersen, S. H., Paidi, M. D., Christen, S. & Lykkesfeldt, Jens, 2012, In: P L o S One. 7, 10, 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Maternal vitamin C deficiency during pregnancy results in transient fetal and placental growth retardation in guinea pigs: [Plus] erratum

    Schjoldager, J. G., Paidi, M. D., Lindblad, M. M., Birck, M. M., Kjærgaard, A. B., Dantzer, V., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2015, In: European Journal of Nutrition. 54, 4, p. 667-676 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs) and transforming growth factor-β (TGF-β) in advanced canine myxomatous mitral valve disease

    Moesgaard, S. G., Aupperle, H., Rajamäki, M. M., Falk, T., Rasmussen, C. E., Zois, N. E. & Olsen, Lisbeth Høier, 2014, In: Research in Veterinary Science. 97, 3, p. 560-567 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction

    Halladin, N. L., Busch, S. V. E., Jensen, S. E., Aarøe, J., Kjærgaard, B., Heegaard, P. M. H., Lykkesfeldt, Jens, Rosenberg, Jacob & Gögenur, Ismail, 2014, In: In Vivo. 28, p. 483-488 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Melatonin suppresses markers of inflammation and oxidative damage in a human daytime endotoxemia model

    Alamili, M., Bendtzen, K., Lykkesfeldt, Jens, Rosenberg, Jacob & Gögenur, Ismail, 2014, In: Journal of Critical Care. 29, 1, p. 184.e9-184.e13 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Microdialysis as a tool for drug quantification in the bronchioles of anaesthetized pigs

    Rottbøll, Lisa Amanda Holm & Friis, C., 2014, In: Basic & Clinical Pharmacology & Toxicology Online. 114, 3, p. 226-232 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Mitral Regurgitation Severity and Left Ventricular Systolic Dimension Predict Survival in Young Cavalier King Charles Spaniels

    Reimann, Maria Josefine, Moller, J. E., Haggstrom, J., Martinussen, Torben, Zatrazemi, S. S. C., Svanholm, L., Nielsen, L. B. M., Pedersen, H. D. & Olsen, Lisbeth Høier, 2017, In: Journal of Veterinary Internal Medicine. 31, 4, p. 1008-1016 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Mitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease

    Reimann, Maria Josefine, Cremer, Signe Emilie, Christiansen, L., Ibragimov, Emil, Gao, Fei, Cirera, Susanna, Fredholm, Merete, Olsen, Lisbeth Høier & Karlskov-Mortensen, Peter, 2024, In: Mammalian Genome. 35, 1, p. 77-89 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Modelling Nonalcoholic Steatohepatitis In Vivo—A Close Transcriptomic Similarity Supports the Guinea Pig Disease Model

    Skat-Rørdam, Josephine, Ipsen, David Højland, Seemann, Ernst Stefan, Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2021, In: Biomedicines. 9, 9, 18 p., 1198.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Modelling nonalcoholic steatohepatitis in vivo—a close transcriptomic similarity supports the guinea pig disease model

    Skat-Rørdam, Josephine, Ipsen, David Højland, Seemann, Ernst Stefan, Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, Sep 2021, In: Biomedicines. 9, 9, 1198.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Modulating the gut microbiota improves glucose tolerance, lipoprotein profile and atherosclerotic plaque development in ApoE-deficient mice

    Rune, Ida, Rolin, B., Larsen, C. S., Nielsen, Dennis Sandris, Kanter, J. E., Bornfeldt, K. E., Lykkesfeldt, Jens, Buschard, K., Kirk, R. K., Christoffersen, B., Fels, J. J., Josefsen, K., Kihl, Pernille & Hansen, Axel Kornerup, 2016, In: P L o S One. 11, 1, 16 p., e0146439.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Molecular drivers of non-alcoholic steatohepatitis are sustained in mild-to-late fibrosis progression in a guinea pig model

    Ipsen, David Højland, Skat-Rørdam, Josephine, Tsamouri, M. M., Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2019, In: Molecular Genetics and Genomics. 294, 3, p. 649–661

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

    Ipsen, David Højland, Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2018, In: Cellular and Molecular Life Sciences. 75, 18, p. 3313-3327 15 p.

    Research output: Contribution to journal › Review › Research › peer-review

  14. Published

    Myocardial Changes in Diabetic and Nondiabetic Nonhuman Primates

    Krog, S., Ludvigsen, Trine Pagh, Nielsen, O. L., Kirk, R. K., Lykkegaard, K., Wulff, E. M., Møller, J. E., Pedersen, H. D. & Olsen, Lisbeth Høier, 2020, In: Veterinary Pathology. 57, 2, p. 332-343 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Myocardial ischemia-reperfusion enhances transcriptional expression of endothelin-1 and vasoconstrictor ETB receptors via the protein kinase MEK-ERK1/2 signaling pathway in rat

    Skovsted, Gry Freja, Kruse, L. S., Berchtold, L. A., Grell, A., Warfvinge, K. & Edvinsson, L., 1 Mar 2017, In: PLOS ONE. 12, 3, 18 p., e0174119.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Myxømatøs mitralklapsygdom hos hund: Medicinsk behandling

    Reimann, Maria Josefine, Christiansen, L. B., Falk, B. T. & Olsen, Lisbeth Høier, 2019, In: Dansk Veterinaertidsskrift. 2019, 11, p. 38-43

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Myxømatøs mitralklapsygdom hos hund: Metoder til diagnostik af behandlingskrævende sygdomsstadier

    Reimann, Maria Josefine, Christiansen, L. B., Falk, T. & Olsen, Lisbeth Høier, 2019, In: Dansk Veterinaertidsskrift. 2019, 9, p. 28-32

    Research output: Contribution to journal › Review › Research › peer-review

  18. Published

    Nanopore sequencing reveals methylation changes associated with obesity in circulating cell-free DNA from Göttingen Minipigs

    Drag, Markus Hodal, Debes, Karina Poulsdóttir, Franck, C. S., Flethøj, M., Lyhne, Mille Kronborg, Møller, J. E., Ludvigsen, Trine Pagh, Jespersen, Thomas, Olsen, Lisbeth Høier & Kilpeläinen, Tuomas O., 2023, In: Epigenetics. 18, 1, 17 p., 2199374.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Natriuretic peptides in cardiometabolic regulation and disease

    Zois, N. E., Bartels, E. D., Hunter, I., Kousholt, B. S., Olsen, Lisbeth Høier & Gøtze, J. P., 2014, In: Nature Reviews Cardiology. 11, 7, p. 403-412 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  20. Published

    Neonatal Vitamin C Deficiency and Impaired Brain Development: A Dose-response Study

    Andersen, S. H., 2014, Copenhagen University.

    Research output: Book/Report › Ph.D. thesis › Research

  21. Published

    Nephrectomized and hepatectomized animal models as tools in preclinical pharmacokinetics

    Vestergaard, Bill, Agersø, H. & Lykkesfeldt, Jens, 2013, In: Basic & Clinical Pharmacology & Toxicology Online. 113, 2, p. 75-86 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    New records of gall midges (Diptera: Cecidomyiidae) from Denmark

    Bruun, Hans Henrik, Haarder, S., Jørgensen, J. & Skuhravá, M., 2014, In: Entomologiske Meddelelser. 82, 1, p. 25-37 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    No effect of melatonin on oxidative stress after laparoscopic cholecystectomy: a randomized placebo-controlled trial

    Kücükakin, B., Klein, M., Lykkesfeldt, Jens, Reiter, R. J., Rosenberg, J. & Gögenür, I., 2010, In: Acta Anaesthesiologica Scandinavica. 54, 9, p. 1121-1127 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial

    Kücükakin, B., Wilhelmsen, M., Lykkesfeldt, Jens, Reiter, R. J., Rosenberg, J. & Gögenur, I., 2010, In: European Journal of Vascular and Endovascular Surgery. 40, 4, p. 461-467 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    No impact of polymorphism in the phosphodiesterase 5A gene in Cavalier King Charles Spaniels on pimobendan-induced inhibition of platelet aggregation response

    Reimann, Maria Josefine, Faisst, D. N., Knold, M., Meurs, K. M., Stern, J. A., Cremer, Signe Emilie, Møller, J. E., Ljungvall, I., Häggström, J. & Olsen, Lisbeth Høier, 2023, In: Journal of Veterinary Internal Medicine. 37, 6, p. 1947-2660

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Non-genetic risk factors in haemophilia A inhibitor management: the danger theory and the use of animal models

    Löfgren, Karin Maria, Søndergaard, H., Skov, Søren & Wiinberg, B., Sep 2016, In: Haemophilia. 22, 5, p. 657-666 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  27. Published

    Non-immunogenic Induced Pluripotent Stem Cells, a Promising Way Forward for Allogenic Transplantations for Neurological Disorders

    Frederiksen, Henriette Reventlow S, Doehn, U., Tveden-Nyborg, Pernille & Freude, Kristine, 2021, In: Frontiers in Genome Editing. 2, 623717.

    Research output: Contribution to journal › Review › Research › peer-review

  28. Published

    Non-terminal blood sampling techniques in Guinea pigs

    Birck, M. M., Tveden-Nyborg, Pernille, Lindblad, M. M. & Lykkesfeldt, Jens, 2014, In: Journal of Visualized Experiments. 92, e51982.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Noninvasive assessment of pulse-wave velocity and flow-mediated vasodilation in anesthetized Göttingen minipigs

    Ludvigsen, Trine Pagh, Wiinberg, N., Jensen, C. J., Callesen, A. T., Andersen, R. W., Jørgensen, A. S. H., Christoffersen, B. Ø., Pedersen, H. D., Moesgaard, S. G. & Olsen, Lisbeth Høier, 2014, In: Comparative Medicine. 64, 6, p. 471-477 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Normal Weight Dyslipidemia: Is It All About the Liver?

    Ipsen, David Højland, Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, Mar 2016, In: Obesity. 24, 3, p. 556-567 12 p.

    Research output: Contribution to journal › Review › Research › peer-review

  31. Published

    Novel traceable CRISPR-Cas9 engineered human embryonic stem cell line (E1C3 + hSEAP + 2xKO + pCD47), has potential to evade immune detection in pigs

    Frederiksen, Henriette Reventlow S, Skov, Søren, Tveden-Nyborg, Pernille, Freude, Kristine & Doehn, U., 7 May 2024, In: Stem Cell Research.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Når leveren bliver for fed

    Ipsen, David Højland, Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2019, In: Aktuel Naturvidenskab. 2019, 3, p. 28-31

    Research output: Contribution to journal › Journal article › Communication

  33. Published

    O11 | In vitro and in vivo effects of dapagliflozin on adenosine diphosphate induced platelet aggregation response in Göttingen minipigs

    Hinz, K., Lyhne, Mille Kronborg, Debes, Karina Poulsdóttir, Reimann, Maria Josefine, Flethøj, M., Bruun, Camilla Vibeke Sichlau, Ludvigsen, Trine Pagh, Kirchhoff, J., Jespersen, Thomas, Pedersen, H. D., Møller, J. E. & Olsen, Lisbeth Høier, 2023, In: Journal of Veterinary Pharmacology and Therapeutics. 46, S1, p. 33 1 p., O11.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  34. Published

    Obese Prone Rats on high- and low-fat diets gain weight equally

    Christensen, B. T., Hellgren, L., Sejrsen, K., Lykkesfeldt, Jens & Hansen, Axel Kornerup, 2010.

    Research output: Contribution to conference › Poster › Research

  35. Published

    Occurrence of Diplostomum pseudospathaceum Niewiadomska, 1984 and D. mergi Dubois, 1932 (Digenea: Diplostomidae) in Danish freshwater snails: ecological and molecular data

    Haarder, S., Jørgensen, K., Kania, Per, Skovgaard, A. & Buchmann, Kurt, 2013, In: Folia Parasitologica. 60, 2, p. 177-180 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    On the effect of vitamin C intake on human health: How to (mis)interprete the clinical evidence

    Lykkesfeldt, Jens, 2020, In: Redox Biology. 34, 13 p., 101532.

    Research output: Contribution to journal › Review › Research › peer-review

  37. Published

    Optimization of pig models for translation of subcutaneous pharmacokinetics of therapeutic proteins: Liraglutide, insulin aspart and insulin detemir

    Pedersen, K., Gradel, Anna Katrina Jógvansdóttir, Ludvigsen, T. P., Christoffersen, B. Ø., Fuglsang-Damgaard, C. A., Bendtsen, K. M., Madsen, S. H., Manfé, V. & Refsgaard, H. H. F., 2022, In: Translational Research. 239, p. 71-84

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Oral LPS Dosing Induces Local Immunological Changes in the Pancreatic Lymph Nodes in Mice

    Kihl, Pernille, Krych, Lukasz, Deng, Ling, Kildemoes, A. O., Laigaard, A., Hansen, L. H., Hansen, Camilla Hartmann Friis, Buschard, K., Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2019, In: Journal of Diabetes Research. 2019, 9 p., 1649279.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Oral insulin does not alter gut microbiota composition of NOD mice

    Kihl, Pernille, Krych, Lukasz, Buschard, K., Wesley, J. D., Kot, W., Hansen, Axel Kornerup, Nielsen, Dennis Sandris & von Herrath, M. G., 2018, In: Diabetes/Metabolism Research and Reviews. 34, 6, 9 p., e3010.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes

    Gillberg, Linn, mxz703, mxz703, Nasif, A., Ohtani, H., Madaj, Z., Hansen, Jakob Werner, Rapin, N., Mogensen, J. B., Liu, M., Dufva, I. H., Lykkesfeldt, Jens, Hajkova, P., Jones, P. A. & Grønbæk, Kirsten, 17 Oct 2019, In: Clinical Epigenetics. 11, 1, p. 143-153 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Oxidative costs of reproduction in mouse strains selected for different levels of food intake and which differ in reproductive performance

    Jothery, A. H. A., Vaanholt, L. M., Mody, N., Arnous, A., Lykkesfeldt, Jens, Bunger, L., Hill, W. G., Mitchell, S. E., Allison, D. B. & Speakman, J. R., 14 Nov 2016, In: Scientific Reports. 6, 12 p., 36353 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Oxidative stress response after laparoscopic versus conventional sigmoid resection: a randomized, double-blind clinical trial

    Madsen, M. T., Kücükakin, B., Lykkesfeldt, Jens, Rosenberg, J. & Gögenur, I., 2012, In: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques. 22, 3, p. 215-219 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Pasteurization Procedures for Donor Human Milk Affect Body Growth, Intestinal Structure, and Resistance against Bacterial Infections in Preterm Pigs

    Li, Y., Nguyen, Duc Ninh, de Waard, M., Christensen, Lars, Zhou, P., Jiang, Pingping, Sun, Jing, Bojesen, Anders Miki, Lauridsen, C., Lykkesfeldt, Jens, Dalsgaard, T. K., Bering, S. B. & Sangild, Per Torp, Jun 2017, In: Journal of Nutrition. 147, 6, p. 1121-1130

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Penetration of antimicrobials to pulmonary epithelial lining fluid and muscle and impact of drug physicochemical properties determined by microdialysis

    Rottbøll, Lisa Amanda Holm & Friis, C., 2016, In: Journal of Pharmacological and Toxicological Methods. 78, p. 58-65 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Peri-operative endothelial dysfunction in patients undergoing minor abdominal surgery: An observational study

    Busch, S. V. E., Godthaab, C., Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Gögenur, I., Feb 2019, In: European Journal of Anaesthesiology. 36, 2, p. 130-134 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Pharmacokinetics of Repeated Oral Dosing with Coenzyme Q10 in Cavalier King Charles Spaniels with Myxomatous Mitral Valve Disease

    Christiansen, L. B., Morsing, Malene Kjelin, Reimann, Maria Josefine, Martinussen, Torben, Birlie, Z., Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Olsen, Lisbeth Høier, 2020, In: Antioxidants. 9, 9 p., 827.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Physiological parameters of endurance horses pre-compared to post-race, correlated with performance: a two race study from Scandinavia

    Larsson, J., Pilborg, P. H., Johansen, M., Christophersen, M. T., Holte, A., Roepstorff, L., Olsen, Lisbeth Høier & Harrison, Adrian Paul, 2013, In: ISRN Veterinary Science. 2013, 12 p., 684353.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Pig models for the human heart failure syndrome

    Hunter, I., Terzic, D., Zois, N. E., Olsen, Lisbeth Høier & Gøtze, J. P., 2014, In: Cardiovascular Endocrinology. 3, 1, p. 15-18 4 p.

    Research output: Contribution to journal › Review › Research › peer-review

  49. Published

    Pigs in space

    Goetze, J. P., Hunter, I., Smith, J. & Hasenkam, J. M., 2013, In: Cardiovascular Endocrinology. 2, 1, p. 4-5 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Piroxicam treatment augments bone abnormalities in interleukin-10 knockout mice

    Holgersen, Kristine, Dobie, R., Farquharson, C., Van't Hof, R., Ahmed, S. F., Hansen, Axel Kornerup & Lindebo Holm, T., Feb 2015, In: Inflammatory Bowel Diseases. 21, 2, p. 257-266 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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