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  1. 2024
  2. Published

    Decreased Heart Rate After Dapagliflozin Treatment In Gottingen Minipigs With Chronic Myocardial Infarction

    Debes, Karina Poulsdóttir, Lyhne, Mille Kronborg, Hinz, K., Sand, K. P., Rose, V. H., Flethøj, M., Ludvigsen, Trine Pagh, Kirchhoff, J., Jespersen, Thomas, Pedersen, H. D., Møller, J. E. & Olsen, Lisbeth Høier, 2024, In: Journal of Cardiac Failure. 30, 1, p. 267-268

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  3. Published

    Mitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease

    Reimann, Maria Josefine, Cremer, Signe Emilie, Christiansen, L., Ibragimov, Emil, Gao, Fei, Cirera, Susanna, Fredholm, Merete, Olsen, Lisbeth Høier & Karlskov-Mortensen, Peter, 2024, In: Mammalian Genome. 35, 1, p. 77-89 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. E-pub ahead of print

    Validation of computed tomography as a diagnostic tool in guinea pigs with non-alcoholic fatty liver disease

    Lintrup, K., Ipsen, David Højland, Skat-Rørdam, Josephine, Lykkesfeldt, Jens, Tveden-Nyborg, Pernille & Buelund, Lene Elisabeth, 2024, (E-pub ahead of print) In: Laboratory Animals.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 2023
  6. Published

    Effect of Remote Ischaemic Preconditioning on Perioperative Endothelial Dysfunction in Non-Cardiac Surgery: A Randomised Clinical Trial

    Wahlstrøm, K. L., Hansen, H. F., Kvist, M., Burcharth, Jakob, Lykkesfeldt, Jens, Gögenur, Ismail & Ekeloef, S., 16 Mar 2023, In: Cells. 12, 6, 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    In vivo effect of rFVIII and rFVIIa in hemophilia A rats evaluated by the Tail Vein Transection Bleeding Model

    Stagaard, Rikke, Øvlisen, Gabi Overgaard, Klæbel, J. H., Danielsen, D., Lund, A., Elm, T. & Ley, C. D., 2023, In: Journal of Thrombosis and Haemostasis. 21, 5, p. 1189-1199 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Dietary Long-Chain Fatty Acids Accelerate Metabolic Dysfunction in Guinea Pigs with Non-Alcoholic Steatohepatitis

    Pedersen, Kamilla, Ipsen, David Højland, Skat-Rørdam, Josephine, Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2023, In: Nutrients. 15, 2445.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Does Aging Affect Vitamin C Status Relative to Intake? Findings from NHANES 2017-2018

    Carr, A. C. & Lykkesfeldt, Jens, 2023, In: Nutrients. 15, 4, 10 p., 892.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Effects of two- and twelve-weeks sodium-glucose cotransporter 2 inhibition on DNA and RNA oxidation: two randomized, placebo-controlled trials

    Larsen, E. L., Andersen, A., Kjær, L. K., Eickhoff, M. K., Frimodt-Møller, M., Persson, F., Rossing, Peter, Lykkesfeldt, Jens, Knop, Filip Krag, Vilsbøll, Tina, Rungby, Jørgen & Poulsen, Henrik Enghusen, 2023, In: Free Radical Research. 57, 2, p. 140-151

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Factors Affecting the Vitamin C Dose-Concentration Relationship: Implications for Global Vitamin C Dietary Recommendations

    Carr, A. C. & Lykkesfeldt, Jens, 2023, In: Nutrients. 15, 7, 19 p., 1657.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Functional and morphological renal changes in a Göttingen Minipig model of obesity-related and diabetic nephropathy

    Christoffersen, B. Ø., Kristensen, C. A., Lindgaard, R., Kirk, R. K., Viuff, B. M., Kvist, P. H., Pedersen, H. D., Ludvigsen, T. P., Skovgaard, T., Fels, J. J., Martinussen, Torben, Christiansen, L. B., Cirera, Susanna & Olsen, Lisbeth Høier, 2023, In: Scientific Reports. 13, 13 p., 6017.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Generation of eight hiPSCs lines from two pathogenic variants in CACNA1A using the CRISPR-Cas9 gene editing technology

    Rivera-Sánchez, P., Søndergaard, L., Wathikthinnakon, Methi, B. D. Magnusson, H., Frederiksen, Henriette Reventlow S, Aabæk Hammer, F., Taleb, R., Christian Cassidy, C., Tranholm Bruun, M., Tümer, Asuman Zeynep, Holst, B., Brasch-Andersen, C., Møller, R., Freude, Kristine & Chandrasekaran, Abinaya, 2023, In: Stem Cell Research. 71, 103193.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Increased meal-induced neurotensin response predicts successful maintenance of weight loss: Data from a randomized controlled trial

    Brethvad, Annemette Overgaard, Zakariassen, Hannah Louise, Holt, Joachim, Lundgren, J. R., Jakobsen, A., Hartmann, Bolette, Lehmann, E. W., Kissow, Hannelouise, Holst, Jens Juul, Madsbad, Sten, Torekov, Signe Sørensen & Holst, Birgitte, 2023, In: Metabolism: Clinical and Experimental. 143, 8 p., 155534.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Influence of general anaesthesia on circulating biomarkers of glucose metabolism in pigs

    Christoffersen, B. Ø., Bundgaard, C. J., Hjøllund, K. R., Fels, J. J., Boll, K. K., Lyhne, Mille Kronborg & Olsen, Lisbeth Høier, 2023, In: Laboratory Animals. 57, 6, p. 650-663

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Nanopore sequencing reveals methylation changes associated with obesity in circulating cell-free DNA from Göttingen Minipigs

    Drag, Markus Hodal, Debes, Karina Poulsdóttir, Franck, C. S., Flethøj, M., Lyhne, Mille Kronborg, Møller, J. E., Ludvigsen, Trine Pagh, Jespersen, Thomas, Olsen, Lisbeth Høier & Kilpeläinen, Tuomas O., 2023, In: Epigenetics. 18, 1, 17 p., 2199374.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    No impact of polymorphism in the phosphodiesterase 5A gene in Cavalier King Charles Spaniels on pimobendan-induced inhibition of platelet aggregation response

    Reimann, Maria Josefine, Faisst, D. N., Knold, M., Meurs, K. M., Stern, J. A., Cremer, Signe Emilie, Møller, J. E., Ljungvall, I., Häggström, J. & Olsen, Lisbeth Høier, 2023, In: Journal of Veterinary Internal Medicine. 37, 6, p. 1947-2660

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    O11 | In vitro and in vivo effects of dapagliflozin on adenosine diphosphate induced platelet aggregation response in Göttingen minipigs

    Hinz, K., Lyhne, Mille Kronborg, Debes, Karina Poulsdóttir, Reimann, Maria Josefine, Flethøj, M., Bruun, Camilla Vibeke Sichlau, Ludvigsen, Trine Pagh, Kirchhoff, J., Jespersen, Thomas, Pedersen, H. D., Møller, J. E. & Olsen, Lisbeth Høier, 2023, In: Journal of Veterinary Pharmacology and Therapeutics. 46, S1, p. 33 1 p., O11.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  19. Published

    Role of S1P-receptor and Rho-kinase in myogenic tone in mesenteric and cerebral arteries of young vs. middle-aged mice

    Skovsted, Gry Freja, Aupetit, A., Björling , K., Haanes, K. A., Syberg, S., Jørgensen, N. R., Freude, Kristine, Pearson, J. T. & Jensen, Lars Jørn, 2023, In: Acta Physiologica. 239, S728, e14042.

    Research output: Contribution to journal › Conference abstract in journal › Communication

  20. Published

    The dietary regulation of LEAP2 depends on meal composition in mice

    Gradel, Anna Katrina Jógvansdóttir, Holm, Stephanie Kjærulff, Byberg, Sarah, Merkestein, M., Hogendorf, W. F. J., Lund, M. L., Buijink, Jesse A., Damgaard, J., Lykkesfeldt, Jens & Holst, Birgitte, 2023, In: FASEB Journal. 37, 6, 21 p., 22923.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    The intestinal permeability marker FITC-dextran 4kDa should be dosed according to lean body mass in obese mice

    Voetmann, Louise Marie, Rolin, B., Kirk, R. K., Pyke, C. & Hansen, Axel Kornerup, 2023, In: Nutrition and Diabetes. 13, 1.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Vitamin C – a scoping review for Nordic Nutrition Recommendations 2023

    Lykkesfeldt, Jens & Carr, A. C., 2023, In: Food and Nutrition Research. 67, 19 p., 10300.

    Research output: Contribution to journal › Review › Research › peer-review

  23. 2022
  24. Published

    A long‐term energy‐rich diet increases prefrontal bdnf in sprague‐dawley rats

    Virtuoso, Alessandro, Tveden-Nyborg, Pernille, Schou‐pedersen, A. M. V., Lykkesfeldt, Jens, Müller, H. K., Elfving, B. & Sørensen, Dorte Bratbo, 2022, In: Nutrients. 14, 1, 126.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    A porcine model of subcutaneous Staphylococcus aureus infection: a pilot study

    Nielsen, O. L., Mellergaard, M., Frees, Dorte, Larsen, M. N., Skov, Søren, Olsen, Lisbeth Høier & Reimann, Maria Josefine, 2022, In: APMIS - Journal of Pathology, Microbiology and Immunology. 130, 7, p. 359-370

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    CTLA4-Ig prevents development of neutralizing antibody formation after continuous treatment with human FVIII in HA rats

    Øvlisen, Gabi Overgaard, Thygesen, P., Weldingh, K. N., Bloem, E., Skov, Søren, Almholt, K., Lövgren, K. M., Ley, C. D. & Holm, T. L., 2022, In: Haemophilia. 28, 4, p. 568-577

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Comparison of the neuromuscular effects of two infusion rates of rocuronium in anesthetized pigs

    Pedersen, Kamilla, Kruhøffer, L. L., Lykkesfeldt, Jens & Kousholt, B. S., 2022, In: Acta Veterinaria Scandinavica. 64, 38.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Effect of gluten-free diet and antibiotics on murine gut microbiota and immune response to tetanus vaccination

    Kihl, Pernille, Krych, Lukasz, Deng, Ling, Hansen, Lars Hestbjerg, Buschard, K., Skov, Søren, Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2022, In: Plos One. 17, 4, 21 p., e0266719.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Effect of the sodium-glucose cotransporter-2 inhibitor dapagliflozinon platelet aggregation response in Cavalier King Charles Spanielswith and without cardiac disease

    Speitzer, A., Øgelund, E., Reimann, Maria Josefine, Møller, J. E., Skovsted, G. F., Lyhne, Mille Kronborg, Verma, S., Ljungvall, I., Häggström, J. & Olsen, Lisbeth Høier, 2022, In: Journal of Veterinary Internal Medicine. 36, 6, p. 2473 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  30. Published

    Efficacy of fibroblast growth factor 21 in non-alcoholic fatty liver disease in guinea pigs

    Klaebel, J. H., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2022, In: Basic & Clinical Pharmacology & Toxicology. 130, 3, p. 385-393

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes

    Lyhne, Mille Kronborg, Debes, Karina Poulsdóttir, Helgogaard, T., Vegge, A., Kildegaard, J., Pedersen-Bjergaard, Ulrik & Olsen, Lisbeth Høier, 2022, In: Journal of Pharmacological and Toxicological Methods. 118, 107221.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Estimation of Vitamin C Intake Requirements Based on Body Weight: Implications for Obesity

    Carr, A. C., Block, G. & Lykkesfeldt, Jens, 2022, In: Nutrients. 14, 7, 8 p., 1460.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Implantation of telemetric blood pressure transmitters in Göttingen Minipigs: Validation of 24-h systemic blood pressure and heart rate monitoring and influence of anaesthesia

    Carlsen, M. F., Christoffersen, B. Ø., Lindgaard, R., Pedersen, H. D. & Olsen, Lisbeth Høier, 2022, In: Journal of Pharmacological and Toxicological Methods. 115, 107168.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    In vitro cell cultures of Brunner's glands from male mouse to study GLP-1 receptor function

    Voetmann, Louise Marie, Underwood, C. R., Rolin, B., Hansen, Axel Kornerup, Kirk, R. K., Pyke, C., Knudsen, L. B. & Frederiksen, K. S., 2022, In: American journal of physiology. Cell physiology. 322, 6, p. C1260-C1269

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Lower Vitamin C Levels Are Associated With Less Improvement in Negative Symptoms in Initially Antipsychotic-Naïve Patients With First-Episode Psychosis

    Myken, A. N., Ebdrup, Bjørn, Sørensen, M. E., Broberg, B. V., Skjerbæk, M. W., Glenthøj, Birte Yding, Lykkesfeldt, Jens & Nielsen, Mette Ødegaard, 2022, In: The international journal of neuropsychopharmacology. 25, 8, p. 613-618 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Marked gut microbiota dysbiosis and increased imidazole propionate are associated with a NASH Göttingen Minipig model

    Lützhøft, Ditte Olsen, Sinioja, T., Christoffersen, B., Jakobsen, Rasmus Riemer, Geng, Dawei, Ahmad, H. F. B., Straarup, E. M., Pedersen, K. M., Kot, Witold, Pedersen, H. D., Cirera, Susanna, Hyötyläinen, T., Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2022, In: BMC Microbiology. 22, 1, 287.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Optimization of pig models for translation of subcutaneous pharmacokinetics of therapeutic proteins: Liraglutide, insulin aspart and insulin detemir

    Pedersen, K., Gradel, Anna Katrina Jógvansdóttir, Ludvigsen, T. P., Christoffersen, B. Ø., Fuglsang-Damgaard, C. A., Bendtsen, K. M., Madsen, S. H., Manfé, V. & Refsgaard, H. H. F., 2022, In: Translational Research. 239, p. 71-84

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Prolonged insulin-induced hypoglycaemia reduces ß-cell activity rather than number in pancreatic islets in non-diabetic rats

    Jensen, Vivi Flou Hjorth, Mølck, A. M., Nowak, J., Fels, J. J., Lykkesfeldt, Jens & Bøgh, I. B., 2022, In: Scientific Reports. 12, 14113.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Semaglutide treatment attenuates vessel remodelling in ApoE−/− mice following vascular injury and blood flow perturbation

    Jensen, Ditte Marie, Skovsted, Gry Freja, Bonde, M. F. B., Bentzon, J. F., Rolin, B., Franck, G., Ougaard, M. K. E., Voetmann, Louise Marie, Bachmann, J. C., Uryga, A., Pyke, C., Kirk, R. K., Hvid, H., Knudsen, L. B., Lykkesfeldt, Jens & Nyberg, M., 2022, In: Atherosclerosis Plus. 49, p. 32-41 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    The G213D variant in Nav1.5 alters sodium current and causes an arrhythmogenic phenotype resulting in a multifocal ectopic Purkinje-related premature contraction phenotype in human-induced pluripotent stem cell-derived cardiomyocytes

    Callø, Kirstine, Geryk, M., Freude, Kristine, Treat, J. A., Vold, V. A., Frederiksen, Henriette Reventlow S, Broendberg, A. K., Frederiksen, T. C., Jensen, H. K. & Cordeiro, J. M., 2022, In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 24, 12, p. 2015–2027

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Vitamin C Deficiency Exacerbates Dysfunction of Atherosclerotic Coronary Arteries in Guinea Pigs Fed a High-Fat Diet

    Skovsted, Gry Freja, Skat-Rørdam, Josephine, Frøkiær, A. P., Jensen, Henrik Elvang, Tveden-Nyborg, Pernille & Lykkesfeldt, Jens, 2022, In: Antioxidants. 11, 11, 2226.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Vitamin C deficiency may delay diet-induced NASH regression in the guinea pig

    Skat-Rørdam, Josephine, Pedersen, Kamilla, Skovsted, Gry Freja, Gregersen, I., Vangsgaard, S., Ipsen, David Højland, Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2022, In: Antioxidants. 11, 1, 69.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. 2021
  44. Published

    Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree

    Bjørnholm, K. D., Ougaard, M. E., Skovsted, Gry Freja, Knudsen, L. B. & Pyke, C., 2021, In: Endocrinology, Diabetes and Metabolism. 4, 3, e00234.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    An Oligosaccharide Rich Diet Increases Akkermansia spp. Bacteria in the Equine Microbiota

    Lindenberg, F. C., Lützhøft, Ditte Olsen, Krych, Lukasz, Fielden, J., Kot, Witold, Frøkiær, Hanne, van Galen, G., Nielsen, Dennis Sandris & Hansen, Axel Kornerup, 2021, In: Frontiers in Microbiology. 12, 666039.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affected

    Christiansen, L. B., Dohlmann, T. L., Ludvigsen, T. P., Parfieniuk, E., Ciborowski, M., Szczerbinski, L., Kretowski, A., Desler, Claus, Tiano, L., Orlando, P., Martinussen, Torben, Olsen, Lisbeth Høier & Larsen, Steen, 2021, In: Scientific Reports. 11, 15 p., 2167.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    BCPT policy for experimental and clinical studies

    Tveden-Nyborg, Pernille, Bergmann, T. K., Jessen, N., Simonsen, U. & Lykkesfeldt, Jens, 2021, In: Basic & Clinical Pharmacology & Toxicology. 128, 1, p. 4-8

    Research output: Contribution to journal › Review › Research › peer-review

  48. Published

    Co-bedding of Preterm Newborn Pigs Reduces Necrotizing Enterocolitis Incidence Independent of Vital Functions and Cortisol Levels

    Brunse, Anders, Peng, Y., Li, Y., Lykkesfeldt, Jens & Sangild, Per Torp, 2021, In: Frontiers in Pediatrics. 9, 636638.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Collagen remodelling and plasma ascorbic acid levels in patients suspected of inherited bleeding disorders harbouring germline variants in collagen‐related genes

    Fager Ferrari, M., Zetterberg, E., Rossing, Caroline Maria, Manon‐jensen, T., Pehrsson, M., Karsdal, M. A., Lykkesfeldt, Jens & Leinoe, E., 2021, In: Haemophilia. 27, 1, p. e69-e77

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Decreased expression of the GLP-1 receptor after segmental artery injury in mice

    Bjørnholm, K. D., Povlsen, G. K., Ougaard, M. E., Pyke, C., Rakipovski, G., Tveden-Nyborg, Pernille, Lykkesfeldt, Jens & Skovsted, Gry Freja, 2021, In: The Journal of endocrinology. 248, 3, p. 289-301 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Depleted myocardial coenzyme Q10 in cavalier king charles spaniels with congestive heart failure due to myxomatous mitral valve disease

    Christiansen, L. B., Reimann, Maria Josefine, Schou-Pedersen, A. M. V., Larsen, Steen, Lykkesfeldt, Jens & Olsen, Lisbeth Høier, 2021, In: Antioxidants. 10, 2, p. 1-13 13 p., 161.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Diet-Dependent Changes of the DNA Methylome Using a Göttingen Minipig Model for Obesity

    Feng, Y., Cirera, Susanna, Taşöz, E., Liu, Y., Olsen, Lisbeth Høier, Christoffersen, B. Ø., Pedersen, H. D., Ludvigsen, T. P., Kirk, R. K., Schumacher-Petersen, Camilla, Deng, Y., Fredholm, Merete & Gao, Fei, 2021, In: Frontiers in Genetics. 12, 632859.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Differential effects of dietary components on glucose intolerance and non‐alcoholic steatohepatitis

    Skat-Rørdam, Josephine, Ipsen, David Højland, Hardam, P. D., Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2021, In: Nutrients. 13, 8, 2523.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Discrepancies in global vitamin C recommendations: a review of RDA criteria and underlying health perspectives

    Carr, A. C. & Lykkesfeldt, Jens, 2021, In: Critical Reviews in Food Science and Nutrition. 61, 5, p. 742-755 14 p.

    Research output: Contribution to journal › Review › Research › peer-review

  55. Published

    Extracellular vesicles as drivers of non-alcoholic fatty liver disease: Small particles with big impact

    Ipsen, David Højland & Tveden-Nyborg, Pernille, 2021, In: Biomedicines. 9, 1, p. 1-13 13 p., 93.

    Research output: Contribution to journal › Review › Research › peer-review

  56. Published

    Food intake rather than blood glucose levels affects the pharmacokinetic profile of insulin aspart in pigs

    Gradel, Anna Katrina Jógvansdóttir, Kildegaard, J., Porsgaard, T., Lykkesfeldt, Jens & Refsgaard, H. H. F., 2021, In: Basic & Clinical Pharmacology & Toxicology. 128, 6, p. 783-794

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Hepatic Stellate Cell Activation and Inactivation in NASH-Fibrosis—Roles as Putative Treatment Targets?

    Zisser, Alexandra, Ipsen, David Højland & Tveden-Nyborg, Pernille, 2021, In: Biomedicines. 9, 4, 365.

    Research output: Contribution to journal › Review › Research › peer-review

  58. Published

    Hyperinsulinaemic hypoglycaemia in non-anaesthetized Göttingen minipigs induces a counter-regulatory endocrine response and electrocardiographic changes

    Lyhne, Mille Kronborg, Vegge, A., Povlsen, G. K., Slaaby, R., Kildegaard, J., Pedersen-Bjergaard, Ulrik & Olsen, Lisbeth Høier, 2021, In: Scientific Reports. 11, 11 p., 5983.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD

    Jensen, Victoria Svop, Fledelius, C., Zachodnik, C., Damgaard, J., Nygaard, H., Tornqvist, K. S., Kirk, R. K., Viuff, B. M., Wulff, E. M., Lykkesfeldt, Jens & Hvid, H., 2021, In: Journal of Translational Medicine. 19, 1, 80.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    Liraglutide treatment improves endothelial function in the Ldlr-/- mouse model of atherosclerosis, and affects genes involved in vascular remodelling and inflammation

    Bjørnholm, K. D., Skovsted, Gry Freja, Mitgaard-Thomsen, A., Rakipovski, G., Tveden-Nyborg, Pernille, Lykkesfeldt, Jens & Povlsen, G. K., 2021, In: Basic & Clinical Pharmacology & Toxicology. 128, 1, p. 103-114

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Modelling Nonalcoholic Steatohepatitis In Vivo—A Close Transcriptomic Similarity Supports the Guinea Pig Disease Model

    Skat-Rørdam, Josephine, Ipsen, David Højland, Seemann, Ernst Stefan, Latta, M., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2021, In: Biomedicines. 9, 9, 18 p., 1198.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    Non-immunogenic Induced Pluripotent Stem Cells, a Promising Way Forward for Allogenic Transplantations for Neurological Disorders

    Frederiksen, Henriette Reventlow S, Doehn, U., Tveden-Nyborg, Pernille & Freude, Kristine, 2021, In: Frontiers in Genome Editing. 2, 623717.

    Research output: Contribution to journal › Review › Research › peer-review

  63. Published

    Polymorphisms in the serotonin transporter gene and circulating concentrations of neurotransmitters in Cavalier King Charles Spaniels with myxomatous mitral valve disease

    Reimann, Maria Josefine, Fredholm, Merete, Cremer, Signe Emilie, Christiansen, L. B., Meurs, K. M., Møller, J. E., Häggström, J., Lykkesfeldt, Jens & Olsen, Lisbeth Høier, 2021, In: Journal of Veterinary Internal Medicine. 35, 6, p. 2596-2606

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Tail vein transection bleeding model in fully anesthetized hemophilia A mice

    Carol Illa, Ariadna, Baumgarten, S., Danielsen, D., Larsen, K., Elm, T., Johansen, P. B., Knudsen, T., Lauritzen, B., Tranholm, M. & Ley, C. D., 2021, In: Journal of Visualized Experiments. 175, 17 p., e62952.

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    Temporal development of dyslipidemia and nonalcoholic fatty liver disease (Nafld) in syrian hamsters fed a high‐fat, high‐fructose, high‐cholesterol diet

    Jensen, Victoria Svop, Fledelius, C., Wulff, E. M., Lykkesfeldt, Jens & Hvid, H., 2021, In: Nutrients. 13, 2, p. 1-18 18 p., 604.

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    The development of nonalcoholic steatohepatitis is subjected to breeder dependent variation in guinea pigs

    Ipsen, David Højland, Agerskov, R. H., Klaebel, J. H., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2021, In: Scientific Reports. 11, 2955.

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    The effect of acetylsalicylic acid and pentoxifylline in guinea pigs with non-alcoholic steatohepatitis

    Ipsen, David Højland, Skat-Rørdam, Josephine, Svenningsen, M., Andersen, Mia Trein, Latta, M., Buelund, Lene Elisabeth, Lintrup, K., Skaarup, R., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2021, In: Basic & Clinical Pharmacology & Toxicology. 128, 4, p. 583-593

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    The genetic consequences of dog breed formation - Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels: [+ correction]

    Axelsson, E., Ljungvall, I., Bhoumik, P., Conn, L. B., Muren, E., Ohlsson, Å., Olsen, L. H., Engdahl, K., Hagman, R., Hanson, J., Kryvokhyzha, D., Pettersson, M., Grenet, O., Moggs, J., Del Rio-Espinola, A., Epe, C., Taillon, B., Tawari, N., Mane, S., Hawkins, T. & 4 others, Hedhammar, Å., Gruet, P., Häggström, J. & Lindblad-Toh, K., 2021, In: PLOS Genetics. 17, 9, 34 p., e1009726.

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    The role of vitamin C in epigenetic cancer therapy

    Mikkelsen, Stine Ulrik, Gillberg, Linn, Lykkesfeldt, Jens & Grønbæk, Kirsten, 2021, In: Free Radical Biology and Medicine. 170, p. 179-193 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    Vitamin C: From Bench to Bedside

    Carr, A. C. & Lykkesfeldt, Jens, 2021, In: Nutrients. 13, 4, 3 p., 1102.

    Research output: Contribution to journal › Editorial › Research › peer-review

  71. Published

    [68Ga]Ga-NODAGA-E[(cRGDyK)]2 Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction

    Bentsen, Simon, Clemmensen, Andreas Høeg, Loft, Mathias Hougaard, Flethøj, M., Debes, Karina Poulsdóttir, Ludvigsen, Trine Pagh, Larsen, C. B., Kirchhoff, J., Olsen, Lisbeth Høier, Møller, J. E., Andersen, Thomas Lund, Johannesen, Helle Hjorth, Jespersen, Thomas & Kjær, Andreas, 2021, In: Diagnostics. 11, 10, 1807.

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. 2020
  73. Published

    The counterregulatory response to hypoglycaemia in the pig

    Gradel, Anna Katrina Jógvansdóttir, Kildegaard, J., Ludvigsen, T. P., Porsgaard, T., Schou-Pedersen, A. M. V., Fels, J. J., Lykkesfeldt, Jens & Refsgaard, H. H. F., Oct 2020, In: Basic & Clinical Pharmacology & Toxicology. 127, 4, p. 278-286

    Research output: Contribution to journal › Journal article › Research › peer-review

  74. Published

    Comparison of sublingual, facial and retro-bulbar blood sampling in mice in relation to animal welfare and blood quality

    Gjendal, K., Kiersgaard, M. K., Abelson, Klas, Sørensen, Dorte Bratbo & Ottesen, J. L., 1 May 2020, In: Journal of Pharmacological and Toxicological Methods. 103, 106680.

    Research output: Contribution to journal › Journal article › Research › peer-review

  75. Published

    In vivo fluorescence molecular tomography of induced haemarthrosis in haemophilic mice: link between bleeding characteristics and development of bone pathology

    Vøls, Kåre Kryger, Kjelgaard-Hansen, M., Ley, C. D., Hansen, Axel Kornerup & Petersen, M., 14 Apr 2020, In: BMC Musculoskeletal Disorders. 21, 1, 10 p., 241.

    Research output: Contribution to journal › Journal article › Research › peer-review

  76. Published

    A systematic Cochrane Review of antioxidant supplementation lung disease for cystic fibrosis

    Ciofu, Oana, Smith, S. & Lykkesfeldt, Jens, 2020, In: Paediatric Respiratory Reviews. 33, p. 28-29

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  77. Published

    Animal Models of Fibrosis in Nonalcoholic Steatohepatitis: Do They Reflect Human Disease?

    Ipsen, David Højland, Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2020, In: Advances in Nutrition. 11, 6, p. 1696–1711

    Research output: Contribution to journal › Review › Research › peer-review

  78. Published

    Ascorbate maintains a low plasma oxygen level

    Injarabian, L., Scherlinger, M., Devin, A., Ransac, S., Lykkesfeldt, Jens & Marteyn, B. S., 2020, In: Scientific Reports. 10, 1, 6 p., 10659.

    Research output: Contribution to journal › Journal article › Research › peer-review

  79. Published

    Betamethasone Treatment for Atopic Dermatitis in Gut Microbiota Transplanted Mice

    Debes, Karina Poulsdóttir, Evdina, N. A., Laigaard, A., Larsen, J. M., Zachariassen, L. F., Hansen, Camilla Hartmann Friis & Hansen, Axel Kornerup, 2020, In: Comparative Medicine. 70, 1, p. 6-15 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  80. Published

    Cardiac adaptation in hibernating, free-ranging Scandinavian Brown Bears (Ursus arctos)

    Jørgensen, P. G., Evans, A., Kindberg, J., Olsen, Lisbeth Høier, Galatius, S. & Fröbert, O., 2020, In: Scientific Reports. 10, 1, 9 p., 247.

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    Central control of energy balance by amylin and calcitonin receptor agonists and their potential for treatment of metabolic diseases

    Zakariassen, Hannah Louise, John, L. M. & Lutz, T. A., 2020, In: Basic & Clinical Pharmacology & Toxicology. 127, 3, p. 163-177

    Research output: Contribution to journal › Review › Research › peer-review

  82. Published

    Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing

    Citerni, C., Kirchhoff, J., Olsen, Lisbeth Høier, Sattler, Stefan M, Gentilini, F., Forni, M., Zannoni, A., Grunnet, Morten, Edvardsson, N., Bentzen, Bo Hjorth & Diness, J. G., 2020, In: Frontiers in Veterinary Science. 7, 12 p., 179.

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Published

    Dietary Intervention Accelerates NASH Resolution Depending on Inflammatory Status with Minor Additive Effects on Hepatic Injury by Vitamin E Supplementation

    Klaebel, J. H., Rakipovski, G., Andersen, B., Lykkesfeldt, Jens & Tveden-Nyborg, Pernille, 2020, In: Antioxidants. 9, 9, 9.

    Research output: Contribution to journal › Journal article › Research › peer-review

  84. Published

    Effect of Repeated Exposure to Isoflurane on Nest Building and Burrowing in Mice

    Gjendal, K., Ottesen, J. L., Olsson, I. A. S. & Sørensen, Dorte Bratbo, 2020, In: Journal of the American Association for Laboratory Animal Science : JAALAS. 59, 1, p. 30-36 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. Published

    Effect of insulin on natriuretic peptide gene expression in porcine heart

    Terzic, D., Zois, N. E., Hunter, I., Christoffersen, Christina, Plomgaard, Peter Stendahl, Olsen, Lisbeth Høier, Jørgensen, Stine Ringholm, Pilegaard, Henriette & Goetze, Jens P. , 2020, In: Peptides. 131, 10 p., 170370.

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Published

    Endothelial dysfunction and myocardial injury after major emergency abdominal surgery: a prospective cohort study

    Ekeloef, S., Oreskov, J. O., Falkenberg, A., Burcharth, J., Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Gögenur, Ismail, 2020, In: BMC Anesthesiology. 20, 9 p., 67.

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. Published

    Fgf21 regulates hepatic metabolic pathways to improve steatosis and inflammation

    Keinicke, H., Sun, G., Mentzel, Caroline M. Junker, Fredholm, Merete, John, L. M., Andersen, B., Raun, K. & Kjaergaard, M., 2020, In: Endocrine Connections. 9, 8, p. 755-768 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. Published

    Formation and Glomerular Deposition of Immune Complexes in Mice Administered Human Antibodies: Evaluation of Dose, Frequency, and Biomarkers

    Boysen, L., Viuff, B. M., Landsy, L. H., Lykkesfeldt, Jens, Raymond, J. T., Price, S. A., Pelzer, H. & Lauritzen, B., 2020, In: Toxicologic Pathology. 48, 4, p. 570-585 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  89. Published

    Hypophosphatemic Hypovitaminosis D Induces Osteomalacia in the Adult Female Rat

    Durup, D., Diaz-delCastillo, M., Morgenlykke, J., Jensen, Lars Thorbjørn, Frandsen, E., Abelson, Klas, Pedersen, L., Lykkesfeldt, Jens, Ding, M., Jørgensen, Niklas Rye, Syberg, S., Petersen, S. & Heegaard, Anne-Marie, 2020, In: Endocrinology. 161, 8, bqaa100.

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Published

    Importance of gestational hypoglycaemia for foetal malformations and skeletal development in rats

    Jensen, Vivi Flou Hjorth, Mølck, A. M., Lykkesfeldt, Jens, Fels, J. J., Andersen, L., Renaut, R., McGuigan, F., Åkesson, K. E. & Bøgh, I. B., 2020, In: Reproductive Toxicology. 91, p. 14-26 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. Published

    Inhibition of KCa2 and Kv11.1 Channels in Pigs With Left Ventricular Dysfunction

    Citerni, C., Kirchhoff, J., Olsen, Lisbeth Høier, Sattler, Stefan M, Grunnet, Morten, Edvardsson, N., Bentzen, Bo Hjorth & Diness, J. G., 2020, In: Frontiers in Pharmacology. 11, 11 p., 556.

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    Initial joint bleed volume in a delayed on-demand treatment setup correlates with subsequent synovial changes in hemophilic mice

    Vøls, Kåre Kryger, Kjelgaard-Hansen, M., Ley, C. D., Hansen, Axel Kornerup & Petersen, M., 2020, In: Animal models and experimental medicine. 3, 2, p. 160-168 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. Published

    Inner histopathologic changes and disproportionate zone volumes in foetal growth plates following gestational hypoglycaemia in rats

    Jensen, Vivi Flou Hjorth, Mølck, A., Bøgh, I. B., Nowak, J., Viuff, B. M., Rasmussen, C. L. M., Voetmann, Louise Marie, Fels, J. J., Madsen, S. H., McGuigan, F. E., Tveden-Nyborg, Pernille, Lykkesfeldt, Jens & Akesson, K. E., 2020, In: Scientific Reports. 10, 1, 13 p., 5609.

    Research output: Contribution to journal › Journal article › Research › peer-review

  94. Published

    Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes

    Andreasen, L. J., Kirk, R. K., Fledelius, C., Yorek, M. A., Lykkesfeldt, Jens & Akerstrom, T., 2020, In: Journal of Diabetes Research. 2020, 13 p., 9626398.

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. Published

    Intermittent mitral regurgitation in Cavalier King Charles spaniels: Short-term progression and influence of stress tests

    Reimann, Maria Josefine, Møller, J. E., Häggström, J., Åkerström, L. L. B., Martinussen, Torben & Olsen, Lisbeth Høier, 2020, In: Veterinary Journal. 258, 105457.

    Research output: Contribution to journal › Journal article › Research › peer-review

  96. Published

    Malnutrition predisposes to endotoxin-induced edema and impaired inflammatory response in parenterally fed piglets

    Bæk, Ole, Fabiansen, C., Friis, Henrik, Ritz, C., Koch, Jørgen, Willesen, Jakob, Heegaard, P. M. H., Lykkesfeldt, Jens, Briend, A., Golden, M. H., Sangild, Per Torp & Thymann, Thomas, 2020, In: Journal of Parenteral and Enteral Nutrition. 44, 4, p. 668-676

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    Myocardial Changes in Diabetic and Nondiabetic Nonhuman Primates

    Krog, S., Ludvigsen, Trine Pagh, Nielsen, O. L., Kirk, R. K., Lykkegaard, K., Wulff, E. M., Møller, J. E., Pedersen, H. D. & Olsen, Lisbeth Høier, 2020, In: Veterinary Pathology. 57, 2, p. 332-343 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    On the effect of vitamin C intake on human health: How to (mis)interprete the clinical evidence

    Lykkesfeldt, Jens, 2020, In: Redox Biology. 34, 13 p., 101532.

    Research output: Contribution to journal › Review › Research › peer-review

  99. Published

    Pharmacokinetics of Repeated Oral Dosing with Coenzyme Q10 in Cavalier King Charles Spaniels with Myxomatous Mitral Valve Disease

    Christiansen, L. B., Morsing, Malene Kjelin, Reimann, Maria Josefine, Martinussen, Torben, Birlie, Z., Schou-Pedersen, A. M. V., Lykkesfeldt, Jens & Olsen, Lisbeth Høier, 2020, In: Antioxidants. 9, 9 p., 827.

    Research output: Contribution to journal › Journal article › Research › peer-review

  100. Published

    Proteoglycan synthesis rate as a novel method to measure blood-induced cartilage degeneration in non-haemophilic and haemophilic rats

    Pulles, A. E., Vøls, Kåre Kryger, Christensen, K. R., Coeleveld, K., Hansen, Axel Kornerup, van Vulpen, L. F. D., Petersen, M., Mastbergen, S. C., Roepstorff, K., Schutgens, R. E. G., Kjelgaard-Hansen, M. & Lafeber, F. P. J. G., 2020, In: Haemophilia. 26, 3, p. e88-e96

    Research output: Contribution to journal › Journal article › Research › peer-review

  101. Published

    Salmon calcitonin distributes into the arcuate nucleus to a subset of NPY neurons in mice

    Zakariassen, Hannah Louise, John, L. M., Lykkesfeldt, Jens, Raun, K., Glendorf, T., Schaffer, L., Lundh, S., Secher, A., Lutz, T. A. & Le Foll, C., 2020, In: Neuropharmacology. 167, 107987.

    Research output: Contribution to journal › Journal article › Research › peer-review

  102. Published

    Subcutaneous Administration of Insulin is Associated With Regional Differences in Injection Depot Variability and Kinetics in The Rat

    Gradel, Anna Katrina Jógvansdóttir, Porsgaard, T., Lykkesfeldt, Jens, Brockhoff, P. M. B., Seested, T. & Refsgaard, H. H. F., 2020, In: Experimental and Clinical Endocrinology and Diabetes. 128, 5, p. 332-338 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  103. Published

    TL1A regulates adipose-resident innate lymphoid immune responses and enables diet-induced obesity in mice

    Tougaard, P., Martinsen, L. O., Lützhøft, Ditte Olsen, Jensen, Henrik Elvang, Flethøj, M., Vandenabeele, P., Pedersen, Anders Elm, Skov, Søren, Hansen, Axel Kornerup & Hansen, Camilla Hartmann Friis, 2020, In: International journal of obesity (2005). 44, p. 1062–1074

    Research output: Contribution to journal › Journal article › Research › peer-review

  104. Published

    The expression signatures in liver and adipose tissue from obese Göttingen Minipigs reveal a predisposition for healthy fat accumulation

    Cirera, Susanna, Taşöz, E., Juul Jacobsen, M., Schumacher-Petersen, Camilla, Østergaard Christoffersen, B., Kaae Kirk, R., Pagh Ludvigsen, T., Hvid, H., Duelund Pedersen, H., Olsen, Lisbeth Høier & Fredholm, Merete, 2020, In: Nutrition and Diabetes. 10, 1, 12 p., 9.

    Research output: Contribution to journal › Journal article › Research › peer-review

  105. Published

    The potential of human milk oligosaccharides to impact the microbiota-gut-brain axis through modulation of the gut microbiota

    Al-Khafaji, A. H., Jepsen, Stine Dam, Christensen, K. R. & Vigsnæs, L. K., 2020, In: Journal of Functional Foods. 74, 104176.

    Research output: Contribution to journal › Review › Research › peer-review

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